RecruitingNot ApplicableNCT05393518

Electroclinical Correlation of Anxiety

Electroclinical Correlation of Anxiety, Evidences From Intracerebral Recordings

Sponsor

University Hospital, Bordeaux

Enrollment

30 participants

Start Date

Oct 11, 2022

Study Type

INTERVENTIONAL

Conditions

Generalized Anxiety Disorder Drug Resistant Epilepsy Anxiety Disorder

Summary

Anxiety disorders have the highest prevalence among mental disorders and cause considerable individual and financial costs. Current treatments do not relieve mental suffering of many patients. Understanding neurobiological mechanisms involved in pathological anxiety is a major scientific challenge.

Eligibility

Min Age: 18 YearsMax Age: 65 Years

Plain Language Summary

Simplified for easier understanding

This study is examining the relationship between brain electrical activity and anxiety in people with drug-resistant epilepsy who are already undergoing a specialized pre-surgical brain monitoring procedure called stereoelectroencephalography (SEEG), where electrodes are implanted temporarily to map where seizures start. Researchers will use these electrodes — already in place for clinical purposes — to also study the brain circuits involved in anxiety. **You may be eligible if...** - You are between 18 and 65 years old - You have epilepsy that has not responded to medication - You are already undergoing a SEEG (implanted brain electrode) assessment as part of your pre-surgical workup **You may NOT be eligible if...** - You are unable to give your own informed consent - You are under legal protection such as guardianship or curatorship - You have a chronic delusional disorder or other severe psychiatric condition Talk to your doctor to see if this trial is right for you.

This summary was AI-generated to explain the trial in plain language. It is not medical advice. Always discuss eligibility with your doctor before enrolling in a clinical trial.

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Interventions

BEHAVIORALAnxiety-induced task

Subjects will be asked to describe their most anxious thoughts and write each of them in a detailed scenario. The scenarios will be based on the answers to the Worry and Anxiety Questionnaire, in order to validate the procedure by a standardized examination. During the task, the scenarios will be successively presented to the subjects, on a digital computer medium in written and oral format. Subjects will be asked to actively focus on these negative thoughts with maximum concern, without seeking to control their emotions.

BEHAVIORALNeuropsychiatric assessment

Screening for depression and anxiety