Electroclinical Correlation of Anxiety
Electroclinical Correlation of Anxiety, Evidences From Intracerebral Recordings
University Hospital, Bordeaux
30 participants
Oct 11, 2022
INTERVENTIONAL
Conditions
Summary
Anxiety disorders have the highest prevalence among mental disorders and cause considerable individual and financial costs. Current treatments do not relieve mental suffering of many patients. Understanding neurobiological mechanisms involved in pathological anxiety is a major scientific challenge.
Eligibility
Inclusion Criteria8
- Man or woman
- Aged 18 to 65;
- With drug-resistant epilepsy
- Benefiting from a phase II pre-surgical assessment with intracerebral electrophysiological exploration by stereo-EEG
- Meeting the DSM-5 diagnostic criteria for generalized anxiety disorder ("pathological" population) or not meeting the DSM-5 diagnostic criteria for generalized anxiety disorder ("control" population)
- WAIS IV full scale IQ \> 75 or IAG \> 81
- Affiliate or beneficiary of a social security scheme
- Giving free, informed consent in writing and signed by the participant and the investigator
Exclusion Criteria6
- Being unable to give personal consent
- Be subject to a measure of legal protection (curatorship, guardianship) or placed under judicial protection;
- Suffer from a chronic delusional disorder (eg: schizophrenia);
- Have a moderate or high risk of suicide assessed using the corresponding section of the structured psychiatric interview called "Mini International Neuropsychiatric Interview" (M.I.N.I. 7.0) or a score \> 2 on item 10 of the MADRS, assessing suicidal risk;
- Being pregnant or breastfeeding
- Have severe and / or decompensated somatic illness other than drug-resistant epilepsy
Interventions
Subjects will be asked to describe their most anxious thoughts and write each of them in a detailed scenario. The scenarios will be based on the answers to the Worry and Anxiety Questionnaire, in order to validate the procedure by a standardized examination. During the task, the scenarios will be successively presented to the subjects, on a digital computer medium in written and oral format. Subjects will be asked to actively focus on these negative thoughts with maximum concern, without seeking to control their emotions.
Screening for depression and anxiety
Locations(1)
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NCT05393518