RecruitingNot ApplicableNCT07221409

Virtual Reality Intervention to Improve Psychological Symptom Burden for Cancer Patients Undergoing Treatment

Pilot Study to Assess Safety, Tolerability and Efficacy of Virtual Reality in Cancer Patients

Sponsor

Mayo Clinic

Enrollment

24 participants

Start Date

Oct 8, 2025

Study Type

INTERVENTIONAL

Conditions

Malignant Solid Neoplasm Cancer Hematopoietic and Lymphoid System Neoplasm Depression Adjustment Disorder Anxiety Disorder

Summary

This clinical trial tests the safety, tolerability, and effectiveness of a virtual reality intervention to improve psychological symptom burden for cancer patients undergoing treatment. Virtual reality (VR) is a technology that allows users to experience and interact with three-dimensional, computer-generated environments that simulate the real world or imagined settings. The VR intervention consists of a preloaded with immersive environments designed to engage the senses through simulated sights and sounds. This may include a walk through of a serene forest, exploring vibrant coral reefs, swimming with dolphins, or standing at the base of a majestic waterfall. These environments are created to provide a relaxing and engaging experience. Completing the VR intervention may be a safe and effective way to improve quality of life, reduce anxiety, enhance focus, and promote healthy living for cancer patients undergoing treatment.

Eligibility

Min Age: 18 YearsMax Age: 90 Years

Plain Language Summary

Simplified for easier understanding

This study is testing whether virtual reality (VR) experiences can reduce psychological distress — such as anxiety, fear, and depression — in cancer patients who are undergoing inpatient or outpatient chemotherapy or bone marrow/immune cell treatments. **You may be eligible if...** - You have a cancer diagnosis - You are between 18 and 90 years old - You are currently receiving inpatient chemotherapy, bone marrow transplant, CAR-T cell therapy, or outpatient chemotherapy **You may NOT be eligible if...** - You have a history of bipolar disorder, major depression, anxiety disorder, PTSD, OCD, psychotic disorder, schizophrenia, personality disorder, or substance use disorder - You have a history of suicidal thoughts or attempts - You have a history of treatment-resistant depression, psychiatric hospitalization, stroke, TIA, epilepsy, electroconvulsive therapy, severe vertigo, or balance disorders Talk to your doctor to see if this trial is right for you.

This summary was AI-generated to explain the trial in plain language. It is not medical advice. Always discuss eligibility with your doctor before enrolling in a clinical trial.

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Interventions

OTHERQuestionnaire Administration

Participants will complete pre- and post-intervention questionnaires to assess symptoms of anxiety, depression, and fatigue.

OTHERVirtual Reality (VR) Intervention

Participants will engage in a single-session immersive Virtual Reality (VR) experience lasting approximately 20-30 minutes. The VR content will include calming, guided experiences such as nature scenes, meditation, or breathing exercises designed to promote relaxation and reduce psychological distress. The intervention will be administered in a clinical setting.

Locations(1)

Mayo Clinic in Florida

Jacksonville, Florida, United States

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NCT07221409

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