RecruitingNot ApplicableNCT05400733

Prandial Metabolic Phenotype in Adults

Sponsor

Texas A&M University

Enrollment

50 participants

Start Date

Jun 24, 2022

Study Type

INTERVENTIONAL

Conditions

Protein metabolism

Summary

Previous studies suggest that changes in metabolism due to the effects of aging might serve as a potential for therapeutic agents. The investigating lab developed a pulse method combining multiple stable isotopes to study multiple metabolic pathways in the same individual simultaneously. By measuring whole-body metabolism in a large group of older adults, the investigators may be able to unravel age-related deterioration in protein turnover (synthesis and breakdown) that contributes to impaired functional capacity. Metabolic profiles could explain differences in pathways in the aging process with special interest in metabolism of amino acids as they have been associated with aging-related disorders.

Eligibility

Min Age: 60 YearsMax Age: 80 Years

Inclusion Criteria6

Age: 60-80, inclusive
Stable body-weight (± 5%) for the past 3 months
Subject is judged to be in satisfactory health based on medical history, physical examination, and laboratory screening evaluations.
Ability to walk, sit down and stand up independently or with walking mobility aids
Ability to lie in supine or elevated position for up to 7 hours
Willingness and ability to comply with the protocol

Exclusion Criteria9

Established diagnosis of current malignancy
History of untreated metabolic diseases including hepatic or renal disorder
Presence of acute illness or metabolically unstable chronic illness
Presence of fever within the last 3 days
Use of short course of oral corticosteroids within 4 weeks preceding study day
(Possible) pregnancy
Failure to give informed consent or Investigator's uncertainty about the willingness or ability of the subject to comply with the protocol requirements
Already enrolled in another clinical trial and that clinical trial interferes with participating in this study
Any other condition according to the PI or nurse that was found during the screening visit, that would interfere with the study or safety of the patient

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Interventions

DIETARY_SUPPLEMENTTotal Amino Acids

Histidine, Isoleucine, Leucine, Lysine, Methionine, Phenylalanine, Threonine, Tryptophan, Valine, Alanine, Arginine, Aspartate, Cystine, Glutamine, Glutamate, Glycine, Proline, Serine, Tyrosine. All supplements are commercially available.

DIETARY_SUPPLEMENTEssential Amino Acids

Histidine, Isoleucine, Leucine, Lysine, Methionine, Phenylalanine, Threonine, Tryptophan, Valine. All supplements are commercially available.

DIETARY_SUPPLEMENTEssential Amino Acids + Hydroxy-methylbutyric acid (HMB)

Histidine, Isoleucine, Leucine, Lysine, Methionine, Phenylalanine, Threonine, Tryptophan, Valine, HMB. All supplements are commercially available.

DIETARY_SUPPLEMENTEssential Amino Acids + Leucine

Histidine, Isoleucine, Leucine, Lysine, Methionine, Phenylalanine, Threonine, Tryptophan, Valine, Extra leucine. All supplements are commercially available.

DIETARY_SUPPLEMENTEssential Amino Acids High

Histidine, Isoleucine, Leucine, Lysine, Methionine, Phenylalanine, Threonine, Tryptophan, Valine. All supplements are commercially available.

DIETARY_SUPPLEMENTPlacebo Water

Water