Prevention of Oxaliplatin-induced Nerve Damage in the Body's Extremities

This study is testing whether a drug that affects nerve function can prevent the painful and sometimes permanent nerve damage in the hands and feet (called peripheral neuropathy) that is commonly caused by the chemotherapy drug oxaliplatin. **You may be eligible if...** - You have been diagnosed with colon or rectal cancer confirmed by biopsy - You are scheduled to receive standard adjuvant (post-surgery) chemotherapy with capecitabine and oxaliplatin - Your overall health is good (ECOG 0–2) - You have provided written and verbal informed consent **You may NOT be eligible if...** - You have pre-existing nerve damage (neuropathy) before starting chemotherapy - You have significant kidney or liver problems - You are unable to communicate in the study language - You are pregnant or breastfeeding Talk to your doctor to see if this trial is right for you.