RecruitingNot ApplicableNCT07095998

Nerve Excitability in Cisplatin-Induced Peripheral Neuropathy

Evaluation of Nerve Excitability in Cisplatin-Induced Peripheral Neuropathy

Sponsor

Ka-Wai Ho

Enrollment

60 participants

Start Date

Jan 31, 2026

Study Type

INTERVENTIONAL

Conditions

Neuropathy Peripheral Neuropathy Peripheral Neuropathy Due to Chemotherapy Neurotoxicity Syndromes

Summary

This study aims to evaluate nerve excitability in participants with cisplatin-induced peripheral neuropathy (cis-PN) using threshold tracking nerve conduction studies (TTNCS). By assessing changes in nerve excitability parameters, the study seeks to enhance understanding of the pathophysiology of cis-PN and identify early markers of neurotoxicity in participants undergoing cisplatin-based chemotherapy.

Eligibility

Min Age: 18 Years

Plain Language Summary

Simplified for easier understanding

This clinical trial is studying Threshold Tracking Nerve Conduction Studies for people with neuropathy, neurotoxicity syndromes, and other related conditions. The study is currently recruiting participants at 2 locations. People eligible for this study include aged 18 Years and older.

This summary was AI-generated to explain the trial in plain language. It is not medical advice. Always discuss eligibility with your doctor before enrolling in a clinical trial.

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Interventions

DIAGNOSTIC_TESTThreshold Tracking Nerve Conduction Studies

Measurement of nerve excitability parameters, including response to sub-threshold pre-pulses and other stimuli. The DS5 0 Isolated Bipolar Constant Current Stimulator is a non-invasive, non-therapeutic device that provides controlled electrical stimuli for detailed function assessment of the superficial radial, superficial peroneal, ulnar, and sural nerves.