Mepolizumab and Physical Activity in Severe Asthma

This study is testing whether a biologic drug called mepolizumab (which targets a protein driving airway inflammation) can improve the ability and willingness to exercise in people with severe, hard-to-control asthma. **You may be eligible if...** - You are between 18 and 75 years old - You have had asthma for at least one year - You have severe asthma that is not well-controlled despite optimal treatment for at least 6 months - Your blood or airway has elevated levels of a type of immune cell called eosinophils **You may NOT be eligible if...** - You have another serious lung disease (such as COPD, pulmonary fibrosis, or lung cancer) - You have significant heart disease limiting your ability to exercise - You are currently a smoker or recent ex-smoker (quit less than 6 months ago) - You are pregnant or breastfeeding Talk to your doctor to see if this trial is right for you.