ClinicalTrialsFinder
RecruitingNot ApplicableNCT05412758

Augmented Response of Volatile Biomarkers in Assessment of Oesophagogastric Cancer (AROMA 1 / BIORESOURCE)

Augmented Response of Volatile Biomarkers in Assessment of Oesophagogastric Cancer

Sponsor

Imperial College London

Enrollment

648 participants

Start Date

Feb 28, 2022

Study Type

INTERVENTIONAL

Conditions

Gastric CancerOesophageal CancerMicrobiomeVolatile Organic CompoundsMicrobioataBreath AnalysisVolatalomicsMetabonomics/LipidomicsMicrobiome AnalysisTranscriptomics

Summary

Cancer of the stomach and oesophagus is among the world's top five cancers. Survival rates are very poor as the disease presents late and early symptoms are non-specific. The study team has developed a non-invasive test for cancers of the stomach and oesophagus based on the detection of volatile organic compounds in exhaled breath. These compounds are known to be produced by both cancers as well as cancer associated bacteria within the gut. The proposed innovation is to improve the accuracy of this test by investigating whether simple metabolic substrates can increase the production of these volatile organic compounds by both the tumour and its associated bacteria.

Eligibility

Min Age: 18 YearsMax Age: 90 Years

Plain Language Summary

Simplified for easier understanding

This study is investigating whether a breath test (analyzing exhaled gases called volatile organic compounds) can be used to detect esophageal or stomach cancer. Researchers want to find non-invasive ways to diagnose these cancers earlier. **You may be eligible if...** - You are between 18 and 90 years old - You have been diagnosed with esophageal or stomach cancer (adenocarcinoma) and have not yet started treatment - Or you are a healthy control with normal or benign upper GI findings on recent endoscopy **You may NOT be eligible if...** - You have squamous cell carcinoma of the esophagus (a different cancer type) - You have had surgery to remove the esophagus or stomach - You have already received chemotherapy for this cancer - You have another active cancer Talk to your doctor to see if this trial is right for you.

This summary was AI-generated to explain the trial in plain language. It is not medical advice. Always discuss eligibility with your doctor before enrolling in a clinical trial.

Interested in this trial?

Get notified about updates and connect with the research team.

Interventions

DIETARY_SUPPLEMENTOral Stimulant Drink

For the AROMA 1 study patients will be requested to consume a nutrient drink (approximately 200 ml) that includes natural ingredients found within a typical human diet. Following consumption of the drink, serial breath tests will be performed to determine varying levels of VOC production in breath

Locations(1)

Imperial College NHS Foundation Trust

London, United Kingdom

View Full Details on ClinicalTrials.gov

For the most up-to-date information, visit the official listing.

Visit

NCT05412758

Related Trials

Surgery in Gastrointestinal Stromal Tumors (GISTs) for Treatment, Tumor Modeling, and Genomic Analysis

NCT045579691 location

Lead-212 PSV359 Therapy for Patients With Solid Tumors

NCT067107567 locations

Effects of Cannabidiol and Tetrahydrocannabinol on Microbiome and Neuroinflammation in HIV

NCT055148991 location

Tumor Cell and DNA Detection in the Blood, Urine and Bone Marrow of Patients With Solid Cancers

NCT028388361 location

Study of Anti-CEACAM5 ADC M9140 in Participants With Advanced Solid Tumors (PROCEADE PanTumor)

NCT0671013281 locations