Oesophageal Cancer Clinical Trials

21 recruiting

Oesophageal Cancer Trials at a Glance

31 actively recruiting trials for oesophageal cancer are listed on ClinicalTrialsFinder across 6 cities in 14 countries. The largest study group is Not Applicable with 7 trials, with the heaviest enrollment activity in London, Nashville, and Oxford. Lead sponsors running oesophageal cancer studies include Imperial College London, University Medical Center Groningen, and Cabrini Clinical Education and Research Institute.

Browse oesophageal cancer trials by phase

Treatments under study

About Oesophageal Cancer Clinical Trials

Looking for clinical trials for Oesophageal Cancer? There are currently 21 studies actively recruiting participants. Clinical trials offer access to new treatments before they are widely available, and every approved therapy in use today was first tested through a clinical trial.

Below you can browse trials, sign up for alerts when new Oesophageal Cancer trials open, and view eligibility criteria for each study. Each listing includes the study phase, locations, and enrollment details.

Frequently Asked Questions

Common questions about Oesophageal Cancer clinical trials

A clinical trial is a carefully designed research study that tests new medical treatments, drugs, devices, or approaches in human volunteers. Every approved medication and treatment available today was proven safe and effective through clinical trials.

All clinical trials are reviewed and approved by Institutional Review Boards (IRBs) — independent committees that evaluate patient safety. Trials follow strict protocols, and your health is monitored closely throughout. You can withdraw at any time.

Not necessarily. Many trials compare the new treatment against the current standard of care, meaning all participants receive active treatment. When placebos are used, they are typically combined with standard treatment, not given alone. The trial description will always specify the design.

Under the Affordable Care Act, most private insurers are required to cover routine patient care costs during a clinical trial. The sponsor typically covers the investigational treatment itself. Medicare also covers routine costs for qualifying trials.

Yes. Participation is completely voluntary. You can withdraw at any time, for any reason, without it affecting your access to standard medical care.

Each trial has specific eligibility criteria — including age, diagnosis, disease stage, prior treatments, and general health. Browse the trials listed above and check their eligibility sections. You can also contact the trial site directly to discuss your situation.

Showing 120 of 31 trials

Recruiting
Phase 1

A Phase 1 Study of the Safety and Tolerability of CTX-10726

Endometrial CancerRenal Cell Carcinoma (RCC)Hepatocellular Carcinoma (HCC)+1 more
Compass Therapeutics70 enrolled3 locationsNCT07419841
Recruiting
Phase 3

PD-1 Inhibitor Combined With Neoadjuvant Chemoradiotherapy Plus Surgery for Locally Advanced ESCC (NEOCRTEC2101)

Esophageal CancerOesophageal CancerSquamous Cell Esophageal Carcinoma
Sun Yat-sen University422 enrolled1 locationNCT05357846
Recruiting

Understanding the Variation of Modern Endoscopic Ultrasound Use in Patients With Oesophageal Cancer (VALUE)

Oesophageal Cancer
University Hospital Southampton NHS Foundation Trust160 enrolled14 locationsNCT06440174
Recruiting
Phase 1

A Phase 1/1b Study of IAM1363 in HER2 Cancers

HER2-positive Breast CancerHER2 + Breast CancerHER2 Mutation-Related Tumors+10 more
Iambic Therapeutics, Inc383 enrolled48 locationsNCT06253871
Recruiting
Phase 2

A Phase 2 Study of Zanidatamab in Patients With HER2-expressing Tumors

Breast CancerEsophageal CancerGastric Cancer+1 more
Jazz Pharmaceuticals200 enrolled21 locationsNCT06695845
Recruiting
Phase 1

A Study of IDE892 as Monotherapy and Combination in MTAP-deleted Advanced Solid Tumors

Gastric AdenocarcinomaBladder CancerMesothelioma+7 more
IDEAYA Biosciences260 enrolled10 locationsNCT07277413
Recruiting

Cancer Loyalty Card Study 2 (CLOCS-2)

Liver CancerPancreatic CancerOvarian Cancer+7 more
Imperial College London2,900 enrolled1 locationNCT06447064
Recruiting
Phase 1

A Phase 1 First-In-Human Study of the Anti-CD73 IPH5301 Alone or in Combination With Chemotherapy and Trastuzumab in Patients With Advanced Solid Tumors

Metastatic Breast CancerEndometrial CancerAdvanced Solid Tumor+6 more
Institut Paoli-Calmettes27 enrolled1 locationNCT05143970
Recruiting

Sample Collection for Ongoing Research and Product Evaluation Study

Breast CancerLiver CancerPancreatic Cancer+9 more
Natera, Inc.9,600 enrolled1 locationNCT07318051
Recruiting
Phase 2

Clinical Study of Adbelimumab in the Adjuvant Treatment of Esophageal Squamous Cell Carcinoma.

Squamous Oesophageal Cancer
Hebei Medical University Fourth Hospital142 enrolled1 locationNCT07266480
Recruiting

REVOLUTION Surgery (REVOLUTION Surgery)

Pancreatic CancerGastric CancerOesophageal Cancer+1 more
University of Edinburgh200 enrolled1 locationNCT05642819
Recruiting

Home Monitoring During Chemoradiation

Locally Advanced Oesophageal Cancer
University Medical Center Groningen30 enrolled1 locationNCT06597240
Recruiting
Not Applicable

Esophageal Self-expandable Metal Stent for Malignant Strictures: a Safety and Efficacy Study

Oesophageal Cancer
Erasmus Medical Center30 enrolled1 locationNCT06364553
Recruiting

Cognitive Impact Associated With Surgery For Gastric Or Esophageal Cancer

SarcopeniaQuality of Life (QOL)Chemotherapy+6 more
Karolinska Institutet130 enrolled1 locationNCT06687291
Recruiting
Phase 2

PULSO Trial: Pulsed Low-Dose-Rate (PLDR) Radiation Chemoradiation (CRT) vs. Standard CRT for Esophageal Cancer

Esophageal CancerOesophageal Cancer
Medical College of Wisconsin50 enrolled1 locationNCT06906887
Recruiting

Volatile Organic Compounds as Breath Biomarkers in Squamous Oesophageal Neoplasms

Oesophageal CancerOesophageal Squamous Cell Carcinoma
Imperial College London518 enrolled13 locationsNCT06169163
Recruiting
Not Applicable

FAZA PETMRI Gastro-Oesophageal Study

Metastasized Gastro-Oesophageal Cancer
University Health Network, Toronto40 enrolled1 locationNCT04560036
Recruiting

The Australia and New Zealand Multicentre Upper Gastrointestinal Endoscopic Tissue Resection Study

Gastric CancerEsophageal NeoplasmsGastric Adenocarcinoma+6 more
Western Sydney Local Health District500 enrolled1 locationNCT05804331
Recruiting

Cardiopulmonary Toxicity of Thoracic Radiotherapy

Oesophageal Cancer
University Medical Center Groningen320 enrolled3 locationsNCT03978377
Recruiting
Phase 2Phase 3

Multicenter Validation Trial of [18F]AlF-FAPI-74 for PET Imaging of Cancer-associated Fibroblasts Through Fibroblast Activation Protein Inhibitors (FAPI) in Different Tumor Types

Gastric CancerPancreatic Ductal AdenocarcinomaOncology+3 more
KU Leuven109 enrolled3 locationsNCT06782412