Mild Traumatic Brain Injury Clinical Trials

51 recruitingLast updated: June 18, 2026

There are 51 actively recruiting mild traumatic brain injury clinical trials across 10 countries. Studies span Not Applicable, Phase 2, Phase 1, Phase 3. Top locations include San Antonio, Texas, United States, Seattle, Washington, United States, Minneapolis, Minnesota, United States. Updated daily from ClinicalTrials.gov.


Mild Traumatic Brain Injury Trials at a Glance

51 actively recruiting trials for mild traumatic brain injury are listed on ClinicalTrialsFinder across 6 cities in 10 countries. The largest study group is Not Applicable with 32 trials, with the heaviest enrollment activity in San Antonio, Seattle, and Minneapolis. Lead sponsors running mild traumatic brain injury studies include VA Office of Research and Development, Henry M. Jackson Foundation for the Advancement of Military Medicine, and Children's Hospital of Philadelphia.

Browse mild traumatic brain injury trials by phase

Treatments under study

About Mild Traumatic Brain Injury Clinical Trials

Looking for clinical trials for Mild Traumatic Brain Injury? There are currently 50 studies actively recruiting participants. Clinical trials offer access to new treatments before they are widely available, and every approved therapy in use today was first tested through a clinical trial.

Below you can browse trials, sign up for alerts when new Mild Traumatic Brain Injury trials open, and view eligibility criteria for each study. Each listing includes the study phase, locations, and enrollment details.

Frequently Asked Questions

Common questions about Mild Traumatic Brain Injury clinical trials

A clinical trial is a carefully designed research study that tests new medical treatments, drugs, devices, or approaches in human volunteers. Every approved medication and treatment available today was proven safe and effective through clinical trials.

All clinical trials are reviewed and approved by Institutional Review Boards (IRBs) — independent committees that evaluate patient safety. Trials follow strict protocols, and your health is monitored closely throughout. You can withdraw at any time.

Not necessarily. Many trials compare the new treatment against the current standard of care, meaning all participants receive active treatment. When placebos are used, they are typically combined with standard treatment, not given alone. The trial description will always specify the design.

Under the Affordable Care Act, most private insurers are required to cover routine patient care costs during a clinical trial. The sponsor typically covers the investigational treatment itself. Medicare also covers routine costs for qualifying trials.

Yes. Participation is completely voluntary. You can withdraw at any time, for any reason, without it affecting your access to standard medical care.

Each trial has specific eligibility criteria — including age, diagnosis, disease stage, prior treatments, and general health. Browse the trials listed above and check their eligibility sections. You can also contact the trial site directly to discuss your situation.

Showing 120 of 51 trials

Recruiting
Not Applicable

Clinical Trial Comparing the Efficacy of Two Teletherapy Programs at Improving Psychological Health in People With Brain Injury

AlexithymiaMild Traumatic Brain Injury
Hackensack Meridian Health300 enrolled3 locationsNCT07436754
Recruiting
Not Applicable

REhabilitation of MEMory Symptoms After BRain Concussion

Mild Traumatic Brain InjuryConcussion, Brain
University of British Columbia184 enrolled8 locationsNCT06956417
Recruiting
Not Applicable

Facilitating Access to Specialty Treatment

Mild Traumatic Brain InjuryConcussion, MildConcussion, Intermediate+1 more
Children's Hospital of Philadelphia210 enrolled1 locationNCT05741411
Recruiting
Phase 3

Growth Hormone Replacement Therapy in Veterans With Mild Traumatic Brain Injury (mTBI) and Adult Growth Hormone Deficiency (AGHD)

Mild Traumatic Brain InjuryAdult Growth Hormone Deficiency
VA Office of Research and Development172 enrolled17 locationsNCT04867317
Recruiting
Not Applicable

Impact of a Paced Breathing Exercise Intervention on Autonomic Nervous System Function After Pediatric Concussion (Acute Phase)

Concussion / Mild Traumatic Brain Injury
McGill University Health Centre/Research Institute of the McGill University Health Centre20 enrolled1 locationNCT07572734
Recruiting
Not Applicable

Non-invasive Stimulation of the Glymphatic System for Slowing Cognitive Decline

Mild Traumatic Brain InjuryPost-Concussion Syndrome
University of Wisconsin, Madison55 enrolled1 locationNCT07044596
Recruiting
Not Applicable

Neuromodulation and Neurorehabilitation for mTBI

Post Traumatic Stress DisorderMild Traumatic Brain Injury
Northwestern University200 enrolled2 locationsNCT03819608
Recruiting
Phase 2

Pathways Relating Amnestic MCI to a Mild Traumatic Brain Injury History

Mild Cognitive ImpairmentAmnestic Mild Cognitive ImpairmentAmnestic Mild Cognitive Disorder+2 more
University of Texas Southwestern Medical Center75 enrolled1 locationNCT05446584
Recruiting
Not Applicable

Acceptance and Commitment Therapy Integrated Vestibular Rehabilitation (ACTIVE) RCT

Mild traumatic brain injury (MTBI)Psychological healthConcussion, Mild+1 more
University of Pittsburgh250 enrolled2 locationsNCT06819904
Recruiting
Not Applicable

Multidimensional Sleep Health Intervention to Optimize Concussion Recovery

TreatmentDepression, AnxietySleep Health+2 more
University of Colorado, Denver54 enrolled1 locationNCT07082218
Recruiting

Recovery Among Older Adults Following Mild TBI

Mild Traumatic Brain Injury
University of Maryland, Baltimore250 enrolled1 locationNCT07569354
Recruiting
Not Applicable

Evaluation of Cognitive Behavioral Therapy for Insomnia (CBT-I) in Individuals With Mild Traumatic Brain Injury (mTBI)

SleepMild Traumatic Brain InjurySleep Architecture+1 more
University of Missouri-Columbia15 enrolled1 locationNCT07385105
Recruiting
Not Applicable

Combined Neuromodulation and Cognitive Training for Post-mTBI Depression

DepressionMild Traumatic Brain InjuryConcussion, Brain
University of California, San Diego72 enrolled1 locationNCT05682677
Recruiting
Not Applicable

rTMS for Military TBI-related Depression

Depressive SymptomsConcussionMild Traumatic Brain Injury
Henry M. Jackson Foundation for the Advancement of Military Medicine198 enrolled3 locationsNCT05426967
Recruiting
Not Applicable

Improving Cognitive Rehabilitation Outcomes

Mild Traumatic Brain InjuryPosttraumatic Stress Disorder
VA Office of Research and Development144 enrolled2 locationsNCT07055633
Recruiting
Not Applicable

CORE (Cognitive Optimization Through Rehabilitation and Education) Study

Mild Traumatic Brain Injury, Concussion
University of Washington354 enrolled2 locationsNCT06859996
Recruiting
Phase 1

Frontal iTBS for Impulsivity and Suicidal Ideation in Veterans With Mild Traumatic Brain Injury

ImpulsivitySuicidal IdeationMild Traumatic Brain Injury
VA Office of Research and Development55 enrolled1 locationNCT05647044
Recruiting
Not Applicable

Symptom Exacerbation Following Mental Imagery in Patients With Persistent Post-Concussive Symptoms

Post-Traumatic HeadacheMild Traumatic Brain Injury, ConcussionPost Concussive Syndrome, Chronic
Reuth Rehabilitation Hospital60 enrolled1 locationNCT07166536
Recruiting
Not Applicable

TES HT100 Clinical Validation for Brain Injury Screening in Patients With Mild Head Trauma or Neurological Symptoms

Intracranial LesionsMild Traumatic Brain InjuryNeurological Symptoms Not Related to Head Trauma
B&B srl850 enrolled1 locationNCT07490418
Recruiting
Not Applicable

Targeting Neuroplasticity for Persistent Post-Concussive Cognitive Symptoms

Mild Traumatic Brain InjuryPersistent Post Concussion Syndrome
University of Minnesota30 enrolled1 locationNCT07246993