RecruitingNot ApplicableNCT05427708

Respiratory Training in the Treatment of Transdiagnostic Pathological Anxiety

Respiratory Training in the Treatment of Transdiagnostic Pathological Anxiety: A Randomized Clinical Trial


Sponsor

University of Texas at Austin

Enrollment

180 participants

Start Date

Aug 22, 2022

Study Type

INTERVENTIONAL

Conditions

Summary

Purpose of the Research: The primary aim of the proposed study is to conduct a randomized parallel-group 2-arm clinical trial investigating capnometry-guided respiratory intervention (CGRI) for pathological anxiety. CGRI aims to raise end-tidal CO2 levels thereby lowering hyperventilation-induced respiratory alkalosis and its associated fear-eliciting somatic reactions. Psycho-education about anxiety and its effects (PsyEd) will serve as a credible control comparator.


Eligibility

Min Age: 18 Years

Plain Language Summary

Simplified for easier understanding

This study is testing whether training people to control their breathing — which can calm the nervous system — helps reduce anxiety across several different anxiety disorders. It is based on the idea that many anxiety disorders share an underlying pattern of dysregulated breathing and arousal. **You may be eligible if:** - You are at least 18 years old - You have clinically elevated anxiety (score of 8 or above on the OASIS scale) - You have one of the following as your primary diagnosis: generalized anxiety disorder, panic disorder, health anxiety, agoraphobia, social anxiety, PTSD, acute stress disorder, or adjustment disorder with anxious mood - You are either not taking psychiatric medications or have been on a stable dose for at least 6 weeks - You can travel to the study lab and speak fluent English **You may NOT be eligible if:** - You have cardiovascular or respiratory conditions, epilepsy, a history of strokes or seizures, or a history of fainting - You are pregnant or breastfeeding - You are currently receiving other psychological treatment for anxiety - You have had a suicide attempt in the past 6 months - You have had psychosis in the past 6 months Talk to your doctor to see if this trial is right for you.

This summary was AI-generated to explain the trial in plain language. It is not medical advice. Always discuss eligibility with your doctor before enrolling in a clinical trial.

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Interventions

DEVICECapnometry-Guided Respiratory Intervention

See: Arm/group descriptions

BEHAVIORALPsycho-Education

See: Arm/group descriptions


Locations(1)

University of Texas at Austin

Austin, Texas, United States

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NCT05427708


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