RecruitingPhase 2NCT05442710

Recovery From Acute Immune Failure in Septic Shock by Immune Cell Extracorporeal Therapy

Sponsor

Artcline GmbH

Enrollment

142 participants

Start Date

Jul 24, 2022

Study Type

INTERVENTIONAL

Conditions

Sepsis, Severe

Summary

Evaluation of a novel therapy approach for severe sepsis patients. Subjects randomized into the treatment arm receive treatment with an immune cell perfusion system on top of standard care. This may contribute to the improvement of the impaired organ function of septic shock patients by assisting the impaired immune system (immune competence enhancement = ARTICE)

Eligibility

Min Age: 18 Years

Plain Language Summary

Simplified for easier understanding

This clinical trial is studying a biological treatment called ARTICE for people with sepsis, severe. The study is currently recruiting participants at 20 locations.

This summary was AI-generated to explain the trial in plain language. It is not medical advice. Always discuss eligibility with your doctor before enrolling in a clinical trial.

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Interventions

BIOLOGICALARTICE

Extracorporal treatment with purified granulocyte concentrate

Locations(20)

Universitätsklinikum Freiburg, Interdisziplinäre Medizinische Intensivtherapie (IMIT)

Freiburg im Breisgau, Baden-Wurttemberg, Germany

Universitätsklinikum Regensburg, Klinik für Anästhesiologie

Regensburg, Bavaria, Germany

Universitätsklinikum Bonn, Klinik und Poliklinik für Anästhesiologie und Operative Intensivmedizin

Bonn, North Rhine-Westphalia, Germany

Universitätsklinikum Köln, Klinik für Anästhesiologie und Operative Intensivmedizin

Cologne, North Rhine-Westphalia, Germany

Helios Klinikum Aue

Aue, Saxony, Germany

Universitätsklinikum Leipzig, Klinik und PK für Anästhesiologie und Intensivtherapie

Leipzig, Saxony, Germany

Universitätsklinikum Halle (Saale), Universitätsklinik für Anästhesiologie und Operative Intensivmedizin

Halle, Saxony-Anhalt, Germany

UNIVERSITÄTSKLINIKUM Schleswig-Holstein Campus Kiel

Kiel, Schleswig-Holstein, Germany

Charité Berlin, Klinik mit Schwerpunkt Nephrologie und internistische Intensivmedizin

Berlin, Germany

Klinikum Braunschweig, Medizinische Klinik V

Braunschweig, Germany

Universitätsklinikum Essen, Klinik für Nephrologie

Essen, Germany

University Hospital Frankfurt, Department of Anaesthesiology, Intensive Care Medicine and Pain Therapy

Frankfurt, Germany

Helios Klinikum HIldesheim

Hildesheim, Germany

Klinikum Magdeburg, Klinik für Intensiv- und Rettungsmedizin

Magdeburg, Germany

University Medical Center Mainz, Study center for Anesthesiology

Mainz, Germany

Universitätsklinikum Mannheim

Mannheim, Germany

University Hospital Minden, Departmenr of Anaesthesiology, intensive and emergency care

Minden, Germany

Klinikum Oldenburg, Universitätsklinik für Anästhesiologie/ Intensivmedizin

Oldenburg, Germany

Universitätsmedizin Rostock, Abteilung KAI

Rostock, Germany

Helios Kliniken Schwerin, Department for intensive care

Schwerin, Germany

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NCT05442710

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