Sepsis, Severe Clinical Trials

11 recruitingLast updated: May 13, 2026

There are 11 actively recruiting sepsis, severe clinical trials across 7 countries. Studies span Not Applicable, Phase 2, Phase 4. Top locations include Amsterdam, North Holland, Netherlands, Atlanta, Georgia, United States, Aue, Saxony, Germany. Updated daily from ClinicalTrials.gov.


Sepsis, Severe Trials at a Glance

11 actively recruiting trials for sepsis, severe are listed on ClinicalTrialsFinder across 6 cities in 7 countries. The largest study group is Not Applicable with 3 trials, with the heaviest enrollment activity in Amsterdam, Atlanta, and Aue. Lead sponsors running sepsis, severe studies include Artcline GmbH, Children's Hospital of Fudan University, and Amsterdam University Medical Centers (UMC), Location Academic Medical Center (AMC).

Browse sepsis, severe trials by phase

Treatments under study

About Sepsis, Severe Clinical Trials

Looking for clinical trials for Sepsis, Severe? There are currently 11 studies actively recruiting participants. Clinical trials offer access to new treatments before they are widely available, and every approved therapy in use today was first tested through a clinical trial.

Below you can browse trials, sign up for alerts when new Sepsis, Severe trials open, and view eligibility criteria for each study. Each listing includes the study phase, locations, and enrollment details.

Frequently Asked Questions

Common questions about Sepsis, Severe clinical trials

A clinical trial is a carefully designed research study that tests new medical treatments, drugs, devices, or approaches in human volunteers. Every approved medication and treatment available today was proven safe and effective through clinical trials.

All clinical trials are reviewed and approved by Institutional Review Boards (IRBs) — independent committees that evaluate patient safety. Trials follow strict protocols, and your health is monitored closely throughout. You can withdraw at any time.

Not necessarily. Many trials compare the new treatment against the current standard of care, meaning all participants receive active treatment. When placebos are used, they are typically combined with standard treatment, not given alone. The trial description will always specify the design.

Under the Affordable Care Act, most private insurers are required to cover routine patient care costs during a clinical trial. The sponsor typically covers the investigational treatment itself. Medicare also covers routine costs for qualifying trials.

Yes. Participation is completely voluntary. You can withdraw at any time, for any reason, without it affecting your access to standard medical care.

Each trial has specific eligibility criteria — including age, diagnosis, disease stage, prior treatments, and general health. Browse the trials listed above and check their eligibility sections. You can also contact the trial site directly to discuss your situation.

Showing 111 of 11 trials

Recruiting

Bispectral Index (BIS) for Classification of Procalcitonin (PCT) Sepsis Grades in Critically Ill Patients With Sepsis

Sepsis, Severe
Suez Canal University20 enrolled1 locationNCT03244293
Recruiting

Sepsis: From Syndrome to Personalized Care

SepsisSeptic ShockSepsis, Severe+1 more
Oslo University Hospital1,950 enrolled1 locationNCT04203979
Recruiting

Treatment Strategy of Human Gamma Globulin on the Therapy for Intensively Ill Children With Inflammatory Storm

Critical IllnessSepsis, Severe
Children's Hospital of Fudan University200 enrolled2 locationsNCT04850456
Recruiting

Role of Transposable Elements in Septic Immune Aging

SepsisSepsis, Septic ShockSepsis and septic shock+5 more
University of California, San Francisco116 enrolled1 locationNCT06809868
Recruiting
Not Applicable

Early Intravenous Hydrocortisone in Sepsis

Sepsis, SevereShock, Septic
Siriraj Hospital230 enrolled1 locationNCT06217939
Recruiting

Towards Novel BIOmarkers to Diagnose SEPsis on the Emergency Room

SepsisInfectionsSeptic Shock+4 more
Amsterdam University Medical Centers (UMC), Location Academic Medical Center (AMC)3,300 enrolled3 locationsNCT06178822
Recruiting
Not Applicable

Reducing Empiric VAncomycin Use in Pediatric Suspected Sepsis

SepsisSeptic ShockSepsis Mrsa+4 more
Children's Hospital of Philadelphia52,500 enrolled4 locationsNCT05975671
Recruiting
Phase 2

Recovery From Acute Immune Failure in Septic Shock by Immune Cell Extracorporeal Therapy

Sepsis, Severe
Artcline GmbH142 enrolled20 locationsNCT05442710
Recruiting
Phase 4

Early Administration of Norepinephrine in Sepsis

Sepsis, Severe
Tunis University200 enrolled1 locationNCT05836272
Recruiting

Monocyte Profiles in Critically Ill Patients With Pseudomonas Aeruginosa Sepsis

SepsisCritically IllSepsis, Severe+6 more
University of Ulm100 enrolled1 locationNCT03044223
Recruiting
Not Applicable

Assessment for Implementation Methods in Sepsis

Septic ShockSepsis, Severe
Rhode Island Hospital10,000 enrolled1 locationNCT05491941