RecruitingPhase 2NCT05446584

Pathways Relating Amnestic MCI to a Mild Traumatic Brain Injury History

Sponsor

University of Texas Southwestern Medical Center

Enrollment

75 participants

Start Date

Apr 20, 2023

Study Type

INTERVENTIONAL

Conditions

Mild Cognitive Impairment Amnestic Mild Cognitive Impairment Amnestic Mild Cognitive Disorder Mild Traumatic Brain Injury Concussion, Brain

Summary

This study will probe if the biological changes in amnestic mild cognitive impairment (aMCI) are related to a history of mild traumatic brain injury (mTBI) using high definition transcranial direct current stimulation (HD-tDCS) and blood-derived biomarker tools. Participants who Do as well as those who Do Not have a history of mTBI will be enrolled in the study.

Eligibility

Min Age: 55 Years

Plain Language Summary

Simplified for easier understanding

This study is exploring whether a history of mild traumatic brain injury (concussion) is a contributing factor in developing a type of mild memory and thinking problem called amnestic mild cognitive impairment (MCI) in older adults. **You may be eligible if...** - You are 55 years or older - You have an active diagnosis of amnestic mild cognitive impairment (a mild but noticeable decline in memory) - You have a history of mild traumatic brain injury (for the mTBI+ group), OR no such history (for the control group) - You are fluent in English **You may NOT be eligible if...** - You had a mild traumatic brain injury within the past year - You have a history of moderate or severe brain injury - You have had a stroke, epilepsy, or brain tumor - You have a current substance use disorder or major psychiatric condition - You have significant vision or hearing problems Talk to your doctor to see if this trial is right for you.

This summary was AI-generated to explain the trial in plain language. It is not medical advice. Always discuss eligibility with your doctor before enrolling in a clinical trial.

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Interventions

DEVICEHigh Definition Transcranial Direct Current Stimulation

HD-tDCS for this study is not intended to be a treatment, and will be applied continuously for 30 minutes at sham (0 mA) or 2 mA for active conditions across 3 consecutive daily sessions to probe neural circuit integrity. This specific HD-tDCS device is completely computer driven, running on a laptop using specialized software. Circular electrodes (12-mm in diameter) filled with conductive gel will be placed in a 4x1 ring configuration with the central electrode being the anode surrounded by four cathodes.