RecruitingPhase 2NCT05447702

Study of Camrelizumab Plus Apatinib and Chemotherapy as Neoadjuvant Therapy in Participants With Triple Negative Breast Cancer (TNBC)

A Single-arm, Prospective Phase II Study of Camrelizumab Plus Apatinib and Chemotherapy as Neoadjuvant Therapy for Triple Negative Breast Cancer (TNBC)


Sponsor

West China Hospital

Enrollment

35 participants

Start Date

Nov 1, 2022

Study Type

INTERVENTIONAL

Conditions

Summary

The purpose of this study is to evaluate the efficacy and safety of camrelizumab in combination with apatinib and chemotherapy as neoadjuvant therapy in participants with triple negative breast cancer (TNBC).


Eligibility

Sex: FEMALEMin Age: 18 YearsMax Age: 75 Years

Plain Language Summary

Simplified for easier understanding

This study is testing a combination of camrelizumab (an immunotherapy), apatinib (a targeted drug), and chemotherapy given before surgery (neoadjuvant treatment) in women with triple negative breast cancer (TNBC) — a type of breast cancer that lacks the three most common receptors — to see if it can shrink the tumor before surgery. **You may be eligible if...** - You are a woman between 18 and 75 years old - You have been newly diagnosed with stage II or III triple negative breast cancer (confirmed by biopsy) - You have not received any prior cancer treatment in the past 12 months - Your overall health and organ function are adequate - You have at least one measurable tumor **You may NOT be eligible if...** - Your breast cancer has spread to other parts of the body (stage IV) - You have bilateral (both breasts) or inflammatory breast cancer - You are pregnant or breastfeeding - You have a significant autoimmune disease Talk to your doctor to see if this trial is right for you.

This summary was AI-generated to explain the trial in plain language. It is not medical advice. Always discuss eligibility with your doctor before enrolling in a clinical trial.

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Interventions

DRUGCamrelizumab

Intravenous (IV) infusion

DRUGApatinib

po.

DRUGNab-paclitaxel

IV infusion.

DRUGEpirubicin

IV infusion.

DRUGCyclophosphamide

IV infusion.


Locations(1)

West China Hospital, Sichuan University

Chengdu, Sichuan, China

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NCT05447702


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