A Study on Predictive Models and Clinical Outcome of Radiation Pneumonitis
A Multicenter Prospective Observational Study on Predictive Models and Clinical Outcome of Radiation Pneumonitis
Huazhong University of Science and Technology
300 participants
Feb 25, 2021
OBSERVATIONAL
Conditions
Summary
Radiation pneumonitis is the main dose-limiting toxicity of thoracic radiotherapy, which can affect life quality, survival, and the tumor-controlling effects of patients receiving thoracic radiotherapy. The purpose of this study is to: * Identify biomarkers including serum proteins, gene expression, genetic changes, and epigenetic modifications that determine radiation pneumonitis. * Investigate the relationship between radiation pneumonitis and other toxicities induced by radiotherapy. * Construct a predictive model for radiation pneumonitis. * Evaluate survival and treatment outcome of patients with radiation pneumonitis.
Eligibility
Inclusion Criteria5
- Clinical diagnosis of lung cancer by histology
- Radiation dose at least 45 Gy
- Karnofsky >60
- Age>18
- Life expectancy of at least 6 months
Exclusion Criteria2
- Previous thoracic irradiation
- Severe cardiopulmonary diseases
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Interventions
blood sample to be taken at baseline, during radiotherapy, and after radiotherapy
Locations(3)
View Full Details on ClinicalTrials.gov
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NCT05448703