RecruitingNot ApplicableNCT05453513

The Neural Underpinnings of Depression and Cannabis Use in Young People Living With HIV

Sponsor

University of Miami

Enrollment

280 participants

Start Date

Apr 1, 2022

Study Type

INTERVENTIONAL

Conditions

Depression HIV Cannabis Use Disorder

Summary

To elucidate mechanisms of substance use disorders (SUD) and comorbid mental illnesses in people living with HIV (PLWH), the study team seeks to investigate reward and pain circuitry in cannabis use and depression comorbidity, two highly prevalent conditions in PLWH. The study team proposes a tightly integrative study to test the overall hypothesis that cannabis use and depression in young PLWH have an additive effect, inducing both reward deficits and pain hypersensitivity, and that this pattern will predict worse outcomes at 1 year follow-up.

Eligibility

Min Age: 18 YearsMax Age: 59 Years

Plain Language Summary

Simplified for easier understanding

This research study uses brain imaging (MRI) to investigate how depression and cannabis use affect brain function in young people living with HIV. The goal is to better understand the brain pathways involved to eventually develop better treatments for depression and substance use in this population. **You may be eligible if...** - You are between 18 and 39 years old and living with HIV (confirmed by lab test or medical records) - You speak English or Spanish fluently - You are in one of these groups: (a) you use cannabis frequently (at least 20 of the last 30 days), (b) you have significant depression symptoms, or (c) both **You may NOT be eligible if...** - You acquired HIV around the time of birth (perinatally) - You are currently pregnant or breastfeeding - You have a substance use disorder for anything other than cannabis or nicotine - You have a serious psychiatric diagnosis such as schizophrenia - You have a known brain injury or neurological condition Talk to your doctor to see if this trial is right for you.

This summary was AI-generated to explain the trial in plain language. It is not medical advice. Always discuss eligibility with your doctor before enrolling in a clinical trial.

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