RecruitingNot ApplicableNCT05454124

Factors in Learning And Plasticity: Macular Degeneration

Characterization of Multiple Factors in Training and Plasticity in Central Vision Loss: Macular Degeneration


Sponsor

University of Alabama at Birmingham

Enrollment

60 participants

Start Date

Nov 1, 2022

Study Type

INTERVENTIONAL

Conditions

Summary

A greater understanding of plasticity after central vision loss can inform new therapies for treating low vision and has the potential to benefit millions of individuals suffering from low vision. The treatment of low vision is particularly relevant to the mission of the NEI to support research on visual disorders, mechanisms of visual function, and preservation of sight. The comparison of different training and outcome factors is in line with the NIMH RDOC framework and studies in an aging population are consistent with the mission of the NIA.


Eligibility

Min Age: 18 YearsMax Age: 89 Years

Plain Language Summary

Simplified for easier understanding

This study examines whether the brain can be trained to improve reading and visual function in people with severe macular degeneration — a condition that causes central vision loss. Researchers use a combination of brain imaging (MRI) and visual training exercises to see if targeted stimulation can help. You may be eligible if: - You are between 18 and 89 years old - You have been diagnosed with macular degeneration by an ophthalmologist - Your vision is 20/100 or worse in both eyes - Your macular function has been severely impaired for at least 2 years - You live within 50 miles of the study site You may NOT be eligible if: - You have a pacemaker or any ferromagnetic metal implant in your body - You have metal implants in your head - You have claustrophobia - You have hearing impairment - You weigh over 300 pounds or your body girth exceeds 60 inches - You have a history of serious head injury - You have hallucinations or delusions - You are pregnant - You have braces or a permanent retainer Talk to your doctor to see if this trial is right for you.

This summary was AI-generated to explain the trial in plain language. It is not medical advice. Always discuss eligibility with your doctor before enrolling in a clinical trial.

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Interventions

BEHAVIORALTraining visual sensitivity

Investigators adopt a standard PL approach to train early visual processes of discriminating the orientation of Gabor patches presented at threshold contrast. Across training blocks, Gabors will range in spatial frequency, where contrast is adapted with a 3/1 staircase. Whenever a specific contrast threshold is reached, spatial frequency will increase by 2 cycles per degree and contrast will be reset. Preliminary data from this method in normally seeing and MD participants show both feasibility and tentative evidence that this training gives rise to improvements in acuity.

BEHAVIORALCombination training

Daily tasks involve a combination of being sensitive to basic visual features, being able to integrate these features, and directing attention and eye movements to better evaluate the information of potential interest. To address this integrative nature of real-world vision, this condition combines elements of training visual sensitivity, spatial integration, and spatial attention.


Locations(1)

UAB

Birmingham, Alabama, United States

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NCT05454124


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