Concurrent Fluorescence and Sonographically Guided Eradication of Contrast-enhancing Gliomas and Metastases

This study is testing a combined approach to brain tumor surgery that uses both fluorescence imaging (a special dye that makes tumor cells glow pink) and ultrasound guidance at the same time, to help surgeons remove more of the tumor while protecting healthy brain tissue. **You may be eligible if...** - You have been newly diagnosed with a single brain tumor that shows contrast enhancement on MRI (suspected high-grade glioma) - You have one or more brain metastases (cancer that has spread to the brain from elsewhere) - You are 18–79 years old and in reasonably good overall health (Karnofsky score 60–100%) **You may NOT be eligible if...** - Your tumor extends into the corpus callosum (bridge between brain halves) or brainstem - You have had previous brain radiation therapy - You have a known allergy to 5-aminolevulinic acid (the fluorescent dye) - You have liver or kidney insufficiency, porphyria, or are pregnant/breastfeeding Talk to your doctor to see if this trial is right for you.