RecruitingNCT05485831

Epidyolex® in Lennox Gastaut, Dravet Syndrome and Tuberous Sclerosis Complex: an Observational Study in ITALY

Observational, Prospective, Multicenter Study of Epidyolex® (Cannabidiol CBD 100 mg/ml) Oral Solution, as Adjunctive Treatment for Seizures Associated With Lennox- Gastaut Syndrome (LGS), Dravet Syndrome (DS) and Tuberous Sclerosis Complex (TSC)


Sponsor

Jazz Pharmaceuticals

Enrollment

100 participants

Start Date

Feb 24, 2025

Study Type

OBSERVATIONAL

Conditions

Summary

This is a prospective, observational study on approximately 70-100 Real World participants affected by LGS, DS, or TSC treated with Epidyolex® as prescribed in the summary of product characteristics. The eligible participants are expected to participate in the study for a duration of 52 weeks of treatment.


Eligibility

Min Age: 2 Years

Inclusion Criteria3

  • Adult patients, and minor patients ≥ 2 years old diagnosed with LGS, DS or TSC.
  • Clinical decision, taken by the physician, to initiate Epidyolex®
  • Adult participants, parents or legal representatives must be willing and able to give informed consent/assent for participation in the study.

Exclusion Criteria1

  • Participants currently using or have used recreational, medicinal cannabis, or cannabinoid-based products within the three months prior to study entry and are unwilling to abstain from these products for the duration of the study.

Interventions

DRUGEpidiolex 100 mg/mL Oral Solution

As prescribed in routine clinical practice in Italy.


Locations(18)

Policlinico Sant'Orsola di Bologna

Bologna, Italy

NPI AOU Mater Domini Università Magna Graecia

Catanzaro, Italy

Università degli studi "G. D'annunzio" Chieti

Chieti, Italy

Azienda Ospedaliera Universitaria Meyer Neurologia Pediatrica

Florence, Italy

Istituto Gaslini Neurologia Pediatrica e Malattie Muscolari

Genova, Italy

AOU Gaetano Martino

Messina, Italy

Centro Regionale Epilessia - ASST Santi Paolo e Carlo

Milan, Italy

ASST Grande Ospedale metropolitano Niguarda

Milan, Italy

Azienda Ospedaliera Universitaria Federico II

Napoli, Italy

AOU Maggiore della Carità di Novara

Novara, Italy

AOU di Padova

Padua, Italy

Policlinico Tor Vergata

Roma, Italy

IRCCS Ospedale Pediatrico Bambin Gesù

Roma, Italy

Fondazione Policlinico Universitario Agostino Gemelli - IRCCS-NPI

Roma, Italy

Azienda Ospedaliero Universitaria Sant'Andrea

Roma, Italy

Ospedale Casa del sollievo e della sofferenza

San Giovanni Rotondo, Italy

AOU Città della Salute PO Molinette

Torino, Italy

Azienda Ospedaliero Universitaria delle Marche

Torrette, Italy

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NCT05485831


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