Cholesterol and Inflammation Lowering Via Bempedoic Acid, an ACL-inhibiting Regimen in HIV Trial (CLEAR HIV Trial)

This study is testing a cholesterol-lowering drug called bempedoic acid in people living with HIV who also have cardiovascular disease or risk factors. People with HIV often have higher levels of inflammation in their arteries, which raises the risk of heart attacks and strokes. Researchers want to see if this drug can reduce both cholesterol and artery inflammation. **You may be eligible if...** - You are living with HIV, aged 40 or older - Your HIV has been well-controlled on antiretroviral therapy for at least 12 weeks - Your CD4 cell count is at least 200 - Your LDL (bad cholesterol) is at least 50 mg/dL - You have a history of heart attack, stroke, peripheral artery disease, or a heart procedure, OR you have at least one cardiovascular risk factor - Women must be post-menopausal or using reliable contraception **You may NOT be eligible if...** - You are pregnant or breastfeeding - You have diabetes requiring insulin - Your blood pressure is severely uncontrolled - You have significant liver, kidney, or blood count problems - You have had cancer in the last 5 years (except certain skin cancers) - You had an acute infection in the last 30 days Talk to your doctor to see if this trial is right for you.