RecruitingNCT07093125

Rehabilitation Practices in Critically Ill Patients Receiving Invasive Mechanical Ventilation in the Intensive Care Unit.

An Observational Study on Rehabilitation Practices in the ICU for Critically Ill Patients Undergoing Invasive Mechanical Ventilation - Report (REPOrt)


Sponsor

Universita degli Studi di Genova

Enrollment

2,400 participants

Start Date

Oct 1, 2025

Study Type

OBSERVATIONAL

Conditions

Summary

This international, multicenter, observational study aims to describe rehabilitation practices in Intensive Care Units (ICUs) worldwide. The primary objective is to provide an overview of current rehabilitation strategies used in ICUs globally. Secondary objectives include assessing the relationship between rehabilitation and key ICU outcomes such as ICU and hospital mortality, length of stay, duration of invasive ventilation, extubation failures, and long-term outcomes including quality of life and functional performance 28 days post-ICU discharge. The study will also compare rehabilitation practices across different geographic and economic regions to identify potential disparities. The study is structured into three modules, with participation contingent on local resources and feasibility. The BASIC Module (mandatory for all centers) gathers fundamental data on rehabilitation practices and their association with patient outcomes. The EXTENDED Module (optional) collects more detailed information on the type, timing, duration, and safety of rehabilitation interventions, including passive exercises, active mobilization, respiratory therapies, dysphagia training, occupational therapy, and cognitive support. The EXTENDED FOLLOW-UP Module (optional) evaluates the patient's quality of life and functional recovery 28 days after ICU discharge. By examining global rehabilitation practices and their impact on patient outcomes, this study aims to improve rehabilitation strategies in ICUs, contributing to better patient care, recovery, and long-term health outcomes.


Eligibility

Min Age: 16 YearsMax Age: 100 Years

Inclusion Criteria4

  • Patients admitted to a participating ICU
  • Adult patients (aged 16 years or older, depending on local regulations for the definition of "adults")
  • Patients who have received invasive ventilation for at least 48 hours
  • Patients who have obtained written informed consent from the patient or next of kin (if local legislation demands so)

Exclusion Criteria1

  • Patients admitted for withdrawn of life sustain therapy

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Locations(1)

IRCCS Ospedale Policlinico San Martino

Genova, Italy, Italy

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NCT07093125


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