RecruitingNCT05500989

PlacEntal Acute Atherosis RefLecting Subclinical Atherosclerosis

Sponsor

Maastricht University Medical Center

Enrollment

226 participants

Start Date

Nov 1, 2016

Study Type

OBSERVATIONAL

Conditions

Pregnancy Pre-Eclampsia Intrauterine Growth Restriction HELLP Syndrome

Summary

Pregnancy is considered a cardiovascular (CV) stress test, and complicated pregnancies are associated with an increased risk for cardiovascular disease (CVD) later in life. Moreover, it is known that often the pregnancy induced CV adaptation does not resolve completely after a short postpartum (PP) period and it is not clear whether these induced changes will resolve over a longer period of time (i.e. in the upcoming months/years after delivery). Understanding the cardiac adaptation during pregnancy and the reversal process in the postpartum period, as well as the factors that influence this these processes, may provide us not only insight in this mechanism, but may help us in identifying factors that may be target points for modification.

Eligibility

Sex: FEMALEMin Age: 18 Years

Plain Language Summary

Simplified for easier understanding

This study is looking at whether changes in the placenta during pregnancy — specifically a condition called acute atherosis (fatty deposits in placental blood vessels) — reflect early signs of atherosclerosis (hardening of arteries) in the mother. It compares women with normal pregnancies to those who develop preeclampsia (dangerous high blood pressure in pregnancy). **You may be eligible if...** - You are a woman 18 or older who is pregnant - You either have an uncomplicated pregnancy OR have been diagnosed with preeclampsia **You may NOT be eligible if...** - You already have chronic high blood pressure being treated with medication (for the uncomplicated pregnancy group) - You have an allergy to glyceryl trinitrate, beta-blockers, or iodinated contrast - You have an autoimmune disorder - You prefer not to have your test results shared with your doctors Talk to your doctor to see if this trial is right for you.

This summary was AI-generated to explain the trial in plain language. It is not medical advice. Always discuss eligibility with your doctor before enrolling in a clinical trial.

Interested in this trial?

Get notified about updates and connect with the research team.