RecruitingNot ApplicableNCT07060144

Cognitive Processing Therapy (CPT) for Perinatal Posttraumatic Stress Disorder (PTSD)

Sponsor

University of Texas at Austin

Enrollment

60 participants

Start Date

Jul 1, 2025

Study Type

INTERVENTIONAL

Conditions

Pregnancy Posttraumatic Stress Disorder (PTSD)

Summary

Pregnant women with a primary diagnosis of posttraumatic stress disorder (PTSD) (PTSD Checklist for DSM-5 (PCL-5) score \> 33) will be randomized to receive conventional cognitive processing therapy (CPT) (60-min session once/week for 12 weeks) or massed CPT (mCPT) (an intensive schedule of 12 60-min sessions over 5 days, approximately 2-3 sessions per day) via telemedicine, for treatment of PTSD. The research aims will be three-fold: (1) Evaluate the relative efficacy and tolerability of CPT vs. mCPT for treatment of perinatal PTSD and depression; (2) Determine the effect of CPT upon maternal-infant attachment and interaction; (3) Collect pilot data of obstetric and neonatal outcomes among those receiving the two CPT delivery schedules.

Eligibility

Sex: FEMALEMin Age: 18 YearsMax Age: 46 Years

Plain Language Summary

Simplified for easier understanding

This study is testing Cognitive Processing Therapy (CPT) — a type of talk therapy proven to work for PTSD — specifically adapted for pregnant women who have experienced trauma and are currently suffering from post-traumatic stress disorder (PTSD). The goal is to treat PTSD during pregnancy before it can affect both mother and baby. **You may be eligible if...** - You are female, between 18 and 46 years of age, and currently pregnant (less than 25 weeks) - You are able to read and write in English - You have experienced at least one traumatic event in your life - You have a primary diagnosis of PTSD confirmed by a clinical interview - If you are on psychiatric medications, your dose has been stable for at least 2 weeks (6 weeks for fluoxetine/Prozac) **You may NOT be eligible if...** - You are not currently pregnant - You have active suicidal intent or are in psychiatric crisis - You are currently in another active trauma-focused psychotherapy - Your psychiatric medications have been recently changed - You have severe cognitive impairment preventing participation Talk to your doctor to see if this trial is right for you.

This summary was AI-generated to explain the trial in plain language. It is not medical advice. Always discuss eligibility with your doctor before enrolling in a clinical trial.

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