RecruitingPhase 2NCT05507138

A Digital Intervention for Post-Stroke Depression and Executive Dysfunction

Efficacy and Target Engagement of a Digital Intervention to Improve Depression and Executive Dysfunction After Stroke

Sponsor

Weill Medical College of Cornell University

Enrollment

70 participants

Start Date

Mar 1, 2023

Study Type

INTERVENTIONAL

Conditions

Depression Stroke Executive Dysfunction

Summary

Individuals with stroke commonly experience both depression and cognitive difficulties. The goal of this study is to evaluate the efficacy of a treatment that combines a digital therapeutic (an iPad-based cognitive training program) with learning cognitive strategies. The hypotheses are that this treatment will improve cognitive skills, depression symptoms, daily function, and brain connectivity. In the short-term, the findings will inform the efficacy of the intervention and in the long-term, may support the use of the intervention to improve co-occurring cognitive and mood difficulties after stroke.

Eligibility

Min Age: 50 YearsMax Age: 79 Years

Inclusion Criteria7

first-time stroke that occurred 6 months or more prior to study initiation
executive dysfunction as defined by a score of less than 1 standard deviation below age-adjusted normative score on at least one test of executive function in the screening assessment
diagnosis of Major Depressive Episode assessed by the Structured Clinical Interview for the DSM-5 (SCID).
at least moderate depressive symptoms as defined by Montgomery Asberg Depression Rating Scale ≥ 18
motor function sufficient to operate an iPad and use a pen, based on self-report and observation
if treated with an antidepressant medication, must be on a stable dose for a minimum of 8 weeks at the time of study enrollment.
able to adhere to all testing and study requirements and willingness to participate in the full study duration

Exclusion Criteria13

receptive aphasia as determined by a score of 2 or 3 on the NIH Stroke Scale \[NIHSS\] item 9 ("Best Language")
dysarthria that makes speech unintelligible (score of 2 on NIHSS item #10)
severe visual impairment or hemispatial neglect (score of 3 on NIHSS item #3 or score of 2 on NIHSS item #11)
patient already enrolled in ongoing concurrent cognitive rehabilitation (note that if a subject is already enrolled in psychotherapy, this will not be grounds for exclusion)
non-fluency in English
presence of or history of significant neurologic or neurodegenerative disorder other than stroke
presence of dementia based on dependence in basic ADLs due to cognitive deficits
history of psychosis or mania (evaluated using the SCID).
active suicide ideation (assessed via the Columbia Suicide Severity Rating Scale)
severe executive dysfunction (based on clinical judgment during screening evaluation) precluding use of the iPad
severe depression-even in the absence of active suicidal ideation-based on the screening evaluation and clinical judgment of the PI, which warrants a higher level of care and/or immediate referral to psychiatric services.
pregnancy
any other clinical or medical reason in the PI's initial screening evaluation that suggests the study is not appropriate for the participant.

Interventions

DEVICEAKL-T01

AKL-T01 is an iPad-based video game designed to improve executive dysfunction and depression symptoms by targeting executive skills (multitasking) and ECN abnormalities.

BEHAVIORALMetacognitive Strategy Training

Metacognitive Strategy Training involves working with a clinician (neuropsychologist or occupational therapist) to learn strategies to manage cognitive difficulties