RecruitingNCT05509010

AI Driven National Platform for CT cOronary Angiography for clinicaL and industriaL applicatiOns Registry

AI Driven National Platform for CT cOronary Angiography for clinicaL and industriaL applicatiOns Registry (APOLLO)


Sponsor

National Heart Centre Singapore

Enrollment

8,000 participants

Start Date

Oct 1, 2021

Study Type

OBSERVATIONAL

Conditions

Summary

The overall aim is to build an AI driven national Platform for CT cOronary angiography for clinicaL and industriaL applicatiOns (APOLLO) for automated anonymization, reporting, Agatston scoring and plaque quantification in CAD. It is a "one-stop" platform spanning diagnosis to clinical management and prognosis, and aid in predicting pharmacotherapy response.


Eligibility

Min Age: 21 YearsMax Age: 80 Years

Inclusion Criteria3

  • Age ≥21 years old
  • Signed informed consent
  • Clinically indicated for evaluation by CTCA

Exclusion Criteria10

  • Individuals unable to provide informed consent
  • Known complex congenital heart disease
  • Planned invasive angiography for reasons other than CAD
  • Non-cardiac illness with life expectancy \< 2 years
  • Pregnancy
  • Concomitant participation in another clinical trial in which subject is subject to investigational drug or device
  • Cardiac event and/or coronary revascularization (percutaneous coronary intervention (PCI) and/or coronary artery bypass grafting (CABG) and/or valvular repair/replacement prior to CTCA
  • Glomerular Filtration Rate ≤ 30mL/min
  • Known allergy to iodinated contrast agent
  • Contraindications to beta blockers or nitroglycerin or adenosine

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Interventions

PROCEDURECTCA

CTCA is performed as part of routine care procedure.


Locations(3)

National Heart Centre Singapore

Singapore, Singapore

National University Hospital

Singapore, Singapore

Tan Tock Seng Hospital

Singapore, Singapore

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NCT05509010


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