Surgical Versus Percutaneous Revascularization in Patients With Reduced Left Ventricular Function (STICH 3.0-NL)
Surgical Versus Percutaneous Revascularization in Patients With Reduced Left Ventricular Function
University Medical Center Groningen
358 participants
May 1, 2026
INTERVENTIONAL
Conditions
Summary
This randomized multicenter trial compares coronary artery bypass grafting (CABG) with percutaneous coronary intervention (PCI) in 358 patients with ischemic left ventricular dysfunction and multivessel coronary disease. The study evaluates differences in survival, major cardiovascular events, and quality of life over 4 years, and contributes to the international STICH 3.0 collaboration assessing long-term outcomes.
Eligibility
Inclusion Criteria6
- Age ≥ 18 years
- LVEF≤ 40%
- Angina pectoris, CCS≥2 and/or hospitalization for ACS or heart failure within 1 year prior to randomization
- Multivessel CAD (2-3 vessel-disease with coronary lesions >70% and involvement of proximal LAD, and/or LM stenosis of >50%). Target vessels are determined by the local Heart Time
- Clinical and angiographical characteristics suitable for isolated coronary revascularization both by CABG or PCI according to the judgment of the local Heart Team
- Written informed consent
Exclusion Criteria6
- ACS < 48 hours before randomization
- Valvular/structural heart disease requiring intervention
- Contra-indications to DAPT
- Non-cardiac condition with life expectancy < 1 year
- Previous CABG
- Decompensated HF at the time of inclusion
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Interventions
CABG (coronary artery bypass grafting)
PCI (percutaneous coronary intervention)
Locations(1)
View Full Details on ClinicalTrials.gov
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NCT07269366