RecruitingPhase 2NCT05511246

Venous Ethanol for Ventricular Tachycardia

Venous Ethanol for Ischemic Left Ventricular Tachycardia


Sponsor

The Methodist Hospital Research Institute

Enrollment

156 participants

Start Date

Apr 12, 2023

Study Type

INTERVENTIONAL

Conditions

Summary

Comparative effectiveness randomized clinical trial, comparing endocardial radiofrequency ablation alone vs radiofrequency ablation combined with venous ethanol in patients with ischemic ventricular tachycardia -Venous Ethanol for Left Ventricular Ischemic Ventricular Tachycardia -VELVET clinical trial


Eligibility

Min Age: 18 YearsMax Age: 85 Years

Plain Language Summary

Simplified for easier understanding

This study is testing whether injecting ethanol into a specific heart vein (venous ethanol ablation) can stop dangerous heart rhythm problems (ventricular tachycardia or VT) in patients with a history of heart attack who also have an implantable defibrillator (ICD). It is tested as an alternative or add-on to standard radiofrequency ablation. You may be eligible if: - You are between 18 and 85 years old with an ICD - You have ischemic cardiomyopathy (heart damage from a prior heart attack) - You have had 3 or more VT episodes in the past 6 months, or at least 1 appropriate ICD shock, or other criteria indicating VT burden - You are a candidate for RF (radiofrequency) ablation for VT You may NOT be eligible if: - Your kidney function is severely reduced (creatinine > 1.5 mg/dL or clearance < 30 ml/min) - Your heart's pumping function is extremely poor (ejection fraction 10% or less) - You have had cardiac surgery in the past 2 months - You are pregnant - You have a blood clot in the heart - You have New York Heart Association Class IV heart failure Talk to your doctor to see if this trial is right for you.

This summary was AI-generated to explain the trial in plain language. It is not medical advice. Always discuss eligibility with your doctor before enrolling in a clinical trial.

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Interventions

DRUGVenous ethanol

Cannulation of coronary vein or veins in the VT substrate and balloon injection of ethanol

PROCEDURECatheter ablation

Endocardial catheter ablation of VT substrate


Locations(1)

Houston Methodist Hospital

Houston, Texas, United States

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NCT05511246


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