RecruitingNCT05516719

Longitudinal Investigation of I2BS in PD

Longitudinal Investigation of Imidazoline-2 Binding Site as a Novel Marker of Disease Progression in Parkinson's Disease: An [11C]BU99008 PET Study

Sponsor

University of Exeter

Enrollment

44 participants

Start Date

Nov 1, 2021

Study Type

OBSERVATIONAL

Conditions

Parkinson Disease Positron Emission Tomography Neurodegenerative Diseases Neurodegeneration Parkinson's Disease Parkinson's

Summary

In this study, the researchers aim to find a biomarker of PD. Using imaging scans called Positron Emission tomography (PET), Single Photon Emission Computed Tomography (SPECT), and Magnetic Resonance Imaging (MRI). The PET and SPECT scans use small amounts of radiation and specific compounds called tracers, to study chemical changes in the brain in a way not possible with any other procedure. The MRI uses magnetic fields to generate images of brain structure and function

Eligibility

Min Age: 25 Years

Plain Language Summary

Simplified for easier understanding

This study is investigating a protein called imidazoline-2 binding sites (I2BS) in people with Parkinson's disease. Researchers are tracking how this protein changes over time, which may help develop better treatments or diagnostic tools for Parkinson's. **You may be eligible if...** - You are 25 years or older - You are able and willing to travel to the research site for study procedures - Women of childbearing age must not be pregnant, not breastfeeding, and must use effective contraception - You are able to understand the study and give written consent **You may NOT be eligible if...** - You are under 25 years old - You are pregnant or breastfeeding - You are unable to use effective contraception (if of childbearing age) - You are unable to travel to the research site - You are unable to follow the study procedures Talk to your doctor to see if this trial is right for you.

This summary was AI-generated to explain the trial in plain language. It is not medical advice. Always discuss eligibility with your doctor before enrolling in a clinical trial.

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Interventions

OTHERPositron Emission Tomography (PET) scan using BU99008 tracer

A positron emission tomography (PET) scan produce detailed 3-dimensional images of the inside of the body by showing radiation from tracers used to highlight specific areas of the brain.

OTHERFP-CIT Single-photon Emission Computed Tomography (SPECT) scan

A single-photon emission computerized tomography (SPECT) scan allows analysis of brain function by creating 3D Pictures using compounds called tracers.

OTHERMagnetic Resonance Imaging (MRI) Scan

MRI (magnetic resonance imaging) uses magnets alongside radio waves to create pictures of the brain.

OTHERLumbar puncture

A lumbar puncture is where a thin needle is inserted between the bones in your lower spine using local anaesthetic. This allows the collection of Cerebrospinal fluid ( CSF)

Locations(1)

University Of Exeter

Exeter, Devon, United Kingdom

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NCT05516719

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