Cushing's Syndrome Before and After Treatment (CORRECT)
Effects of CORtisol Excess and REmission in Cushing's Syndrome Over Time (CORRECT): A Prospective Non-interventional Cohort Study
University of Aarhus
20 participants
Feb 16, 2023
OBSERVATIONAL
Conditions
Summary
The purpose of this study is to prospectively study patients with Cushing's syndrome before and after treatment, with a special emphasis on physical function, quality of life, and circadian rhythms. The hypotheses are: * Cushing's syndrome negatively impacts health-related quality of life (HRQoL) and physical functioning * Cushing's syndrome is associated with altered circadian rhythms at the whole body level and in peripheral target tissues. * These complications partially reverse following disease control.
Eligibility
Inclusion Criteria5
- New (≤ 2 months) diagnosis of Cushing's syndrome (CS) of endogenous etiology:
- ACTH-dependent CS
- ACTH-independent CS
- Age >18 years
- Written informed consent
Exclusion Criteria6
- Active cancer
- Iatrogenic or malignant cause of CS such as adrenocortical carcinoma
- Chronic heart failure (New York Heart Association class IV)
- Chronic kidney disease Chronic Kidney Disease stage ≥3 (eGFR >30 ml/min)
- Liver disease in the form of cirrhosis
- Deemed unable to complete the study safely by investigator
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Interventions
no intervention
Locations(1)
View Full Details on ClinicalTrials.gov
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NCT05521529