RecruitingNot ApplicableNCT05526534

A RCT on the Preventive Effect of HFNC on Postoperative Pulmonary Complications in Patients With Gynecologic Neoplasms

A Randomized Controlled Trial on the Preventive Effect of Heated Humidified High Flow Nasal Cannula Oxygen Therapy on Postoperative Pulmonary Complications in Patients With Gynecologic Neoplasms


Sponsor

Sichuan Cancer Hospital and Research Institute

Enrollment

200 participants

Start Date

Nov 1, 2022

Study Type

INTERVENTIONAL

Conditions

Summary

Patients at high risk of post-operative pulmonary complications (PPC) will be screened out from gynecological tumor patients undergoing surgical treatment, and randomly assigned into the HFNC group and control group, which uses conventional nasal cannula oxygen therapy. The primary outcome is the incidence of PPC, including postoperative hypoxemia, atelectasis, pneumonia, etc. Secondary outcomes are the improvement of postoperative oxygenation, antibiotic use, length of hospital stay, adverse events related to oxygen therapy, etc.


Eligibility

Sex: FEMALEMin Age: 18 YearsMax Age: 90 Years

Plain Language Summary

Simplified for easier understanding

This study is testing whether using high-flow nasal oxygen therapy (HFNC) right after surgery reduces lung complications in women who undergo gynecologic surgery (for either benign or cancerous conditions) and are at higher risk for breathing problems. **You may be eligible if...** - You are 18–90 years old with a gynecologic tumor (benign or malignant) scheduled for surgery - Your surgery is expected to last 2 or more hours - You have at least one risk factor for postoperative lung complications — such as obesity (BMI ≥30), moderate-to-severe asthma, moderate-to-severe COPD, significant smoking history, or a high respiratory risk score **You may NOT be eligible if...** - You have lung metastases or a primary lung cancer - You have had prior lung surgery or radiation to the chest - Your surgery requires bowel resection Talk to your doctor to see if this trial is right for you.

This summary was AI-generated to explain the trial in plain language. It is not medical advice. Always discuss eligibility with your doctor before enrolling in a clinical trial.

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Interventions

DEVICEheated humidified high flow nasal cannula oxygen therapy, HFNC

HFNC can accurately provide 21% \~ 100% oxygen concentration through air oxygen mixer. And through the heating and humidification device to provide 37℃, relative humidity of 100% gas, the maximum flow of 70L/min.

DEVICENasal cannula oxygen

Nasal cannula oxygen has become a routine part of postoperative treatment


Locations(1)

Sichuan Cancer Hospital and Research Institute

Chengdu, Sichuan, China

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NCT05526534


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