RecruitingNot ApplicableNCT05527210

Prebiotic Treatment in People With Schizophrenia


Sponsor

University of Maryland, Baltimore

Enrollment

60 participants

Start Date

Jan 25, 2023

Study Type

INTERVENTIONAL

Conditions

Summary

The proposed project is based on the observation that schizophrenia is characterized by a chronic pro-inflammatory state, which contributes to the severity of a number of the clinical manifestations of the illness, including cognitive impairments, the treatment of which represents a critically important unmet therapeutic need.


Eligibility

Min Age: 18 YearsMax Age: 60 Years

Plain Language Summary

Simplified for easier understanding

This study is testing whether a prebiotic supplement (a dietary fiber that feeds beneficial gut bacteria) can improve symptoms and overall wellbeing in people with schizophrenia or schizoaffective disorder. The idea is that the gut and the brain are connected, and improving gut health may help with mental health. **You may be eligible if...** - You are 18–60 years old with a diagnosis of schizophrenia or schizoaffective disorder - Your condition is currently stable, as determined by your treating psychiatrist - You are currently taking an antipsychotic medication at a stable dose (no changes in the last 14 days) - Your BMI is 40 or under - You can participate in the consent process **You may NOT be eligible if...** - You have a significant gastrointestinal condition like Crohn's disease, IBS, or celiac disease - You have a brain injury, epilepsy, or intellectual disability - You have taken antibiotics recently, or used a probiotic or prebiotic in the last 3 months - You are pregnant or breastfeeding - You have active alcohol or substance misuse (other than mild marijuana use) - You cannot understand English Talk to your doctor to see if this trial is right for you.

This summary was AI-generated to explain the trial in plain language. It is not medical advice. Always discuss eligibility with your doctor before enrolling in a clinical trial.

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Interventions

DIETARY_SUPPLEMENTPrebiotic

Prebiotin® is a fine, white to slightly yellow powder, which is mixed into water and has a slightly sweet taste.

DIETARY_SUPPLEMENTPlacebo Prebiotic

Placebo prebiotic mixed into water


Locations(1)

Maryland Psyciatric Research Center

Catonsville, Maryland, United States

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NCT05527210


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