RecruitingNot ApplicableNCT05529264

Human Intracranial Electrophysiology

Sponsor

Dartmouth-Hitchcock Medical Center

Enrollment

175 participants

Start Date

Jan 17, 2023

Study Type

INTERVENTIONAL

Conditions

Epilepsy

Summary

This study will enroll patients with epilepsy who are being evaluated for epilepsy surgery and have electrodes implanted in the brain and/or have electrodes on the scalp. Additionally, this study will recruit normal and online controls (participants who do not have epilepsy). Participants will be asked to participate in 1 to 2 (30-90 minutes) daily sessions designed to test aspects of human cognition such as memory, speech, language, feeling, movement, attention, sound perception, and emotions. Generally, this will involve working on a computer, looking at pictures or watching videos, and answering questions. Additionally, participants may be asked to be hooked up to additional equipment such as eye tracker, electrical stimulator, heart rate monitor, sweat monitor or other non-invasive equipment. The overall aim of this study is to use human intracranial electrophysiology (the recording of the electrical activity of the human brain) to study localization and function of the human brain.

Eligibility

Min Age: 18 Years

Inclusion Criteria6

Patients must be age 18 years or older. There is no upper age limit.
Patients must have a diagnosis of refractory epilepsy undergoing intracranial EEG recording for clinical purposes.
Patients must be age 18 years or older. There is no upper age limit.
Patients must have a probable diagnosis of epilepsy.
Participants must be age 18 years or older. There is no upper age limit.
Participants must be able to provide informed consent for themselves.

Exclusion Criteria5

Patient has additional neurological condition (such as stroke or dementia) or a psychiatric condition (such as active psychosis or suicidal ideation) and are deemed inappropriate for the study
Patients are not able to provide informed consent for any reason (e.g. encephalopathic, experiencing a seizure)
Patient has additional neurological condition (such as stroke or dementia) or a psychiatric condition (such as active psychosis or suicidal ideation) and are deemed inappropriate for the study
Patients are not able to provide informed consent for any reason (e.g. encephalopathic, experiencing a seizure)
Determined not to be appropriate normal control for the study population

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Interventions

OTHERMemory Tasks

Participants will be asked to view pictures and videos presented on a computer screen and will be asked to recall the details of presented pictures or videos sometime later.

OTHERAttention/arousal tasks

Participants will be asked to perform a continuous performance task, such as continuous addition of numbers. Additionally, participants may be presented with images and may be asked to rate the significance or arousal values for each image.

OTHERLanguage tasks

Participants will be asked to view pictures of actions or things and will be asked to name them. Participants may also be asked to read words or passages.

OTHERVisuospatial tasks

Participants will be asked to copy 3 dimensional designs or make judgements of angle size.

OTHERAuditory Tasks

Participants will be presented with short, approximately 8-minute clips of music from various genres ( i.e. classical, country, rock, etc.) with an attention task (modified sustained attention to response task) nested within each trial. Participants will receive approximately 8 music stimuli and 1 control stimulus (pink noise) twice over the course of two testing sessions ( 90 mins each). Additionally, participants will be asked to answer questions about their hearing, music preferences/training, and certain demographic information (age, handedness, and language proficiency).

PROCEDUREBrain Stimulation

A brain stimulator will be used to understand new functions of the brain. Participants will be presented with pictures on a computer screen and may be asked to tell researchers what is seen or remembered by participants. As pictures are viewed by the participants, the brain stimulator may be activated, which would not be something that would be felt by an individual participant.

OTHERSocial Emotional Task

Participants will be asked to view presented pictures and videos of people engaged in social interaction. Additionally, participants will be presented with the standardized tasks that are designed to help the researchers with understanding the nature of emotions. Some of these images may be emotionally disturbing. If participants are not comfortable viewing such images, they will be asked to refrain from participation in this study.

OTHERRecording of facial expressions

Some participants may be asked permission to record the video of their facial expressions during performance of a research task. Generally, this will include only research tasks investigating brain representation of social/emotional information. Automated analysis of facial expression may be used in certain experiments to provide information on experience of emotional states such as happiness and sadness related to the images being presented.

OTHERJudgement/Impulsivity Task

Certain study participants may be enrolled into research tasks designed to activate regions important for judgment and impulse control. These tasks will present participants with choices of varying monetary rewards and ask them to make judgements to measure one's tendency to prefer immediate over delayed rewards.