RecruitingNot ApplicableNCT05536076

Effect of Hypercapnia Treatment on Respiratory Recovery After Spinal Cord Injury

Sponsor

VA Office of Research and Development

Enrollment

30 participants

Start Date

Mar 1, 2023

Study Type

INTERVENTIONAL

Conditions

Sleep Apnea Hypercapnia SCI/D

Summary

It is estimated that 1,275,000 people in the United States alone live with spinal cord injury, including around 100,000 Veterans with spinal cord injury, making the V.A. the largest integrated health care system in the world for spinal cord injuries injury care. New therapies are needed to prevent the morbidities and mortalities associated with the high prevalence of respiratory disorders in Veterans with spinal cord injury. The current research project and future studies would set the base for developing innovative therapies for this disorder. This proposal addresses a new therapeutic intervention for sleep apnea in spinal cord injury. The investigators hypothesized that daily hypercapnia treatments improve respiratory symptoms and alleviate sleep apnea in patients with chronic spinal cord injury. The investigators will perform a pilot study to examine the impact of daily hypercapnia treatments for-two week durations among Veterans with spinal cord injury. The investigators believe that this novel approach to treating sleep apnea and will yield significant new knowledge that improves the health and quality of life of these patients.

Eligibility

Min Age: 18 YearsMax Age: 89 Years

Plain Language Summary

Simplified for easier understanding

This study explores whether breathing slightly elevated levels of CO2 (a technique called hypercapnia treatment) can help restore breathing function in people with spinal cord injuries. It also includes people without spinal cord injuries who have obstructive sleep apnea (OSA) as a comparison group. You may be eligible if: - You are between 18 and 89 years old - You have a chronic spinal cord injury (more than 6 months ago) AND evidence of sleep-disordered breathing, OR - You are an able-bodied person with obstructive sleep apnea You may NOT be eligible if: - You are on continuous mechanical ventilation - You have severe heart failure (ejection fraction below 35%) - You have had a recent stroke, heart attack, or major surgery - You have a history of alcohol or substance abuse within the last 90 days - You already have elevated CO2 levels while breathing normally - You are unable to give your own consent Talk to your doctor to see if this trial is right for you.

This summary was AI-generated to explain the trial in plain language. It is not medical advice. Always discuss eligibility with your doctor before enrolling in a clinical trial.

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