Effects of Psilocybin in Obsessive Compulsive Disorder

This study is testing psilocybin (the active compound in "magic mushrooms") as a treatment for people with obsessive-compulsive disorder (OCD) that hasn't fully responded to previous treatments. Researchers are exploring whether a carefully supervised dose can reduce OCD symptoms. **You may be eligible if...** - You have been diagnosed with OCD for at least 1 year - Your OCD symptoms are at a moderate-to-severe level (Y-BOCS score of 18 or more) - You have tried at least one previous treatment (therapy or medication) for OCD - You are not currently on antidepressants (or can safely stop them) - You are considered low risk for suicide **You may NOT be eligible if...** - You have a personal or family history of psychosis, schizophrenia, or bipolar disorder - You have a history of serious heart or liver conditions - You are pregnant or breastfeeding - You have an active substance use disorder - You are currently taking antidepressants you cannot stop Talk to your doctor to see if this trial is right for you.