RecruitingNot ApplicableNCT05570552

1/2- Bangladesh Center for Global Environmental and Occupational Health- Bangladesh

Long Term Effects of Household Air Pollution (HAP) Reduction on Cardio-pulmonary and Immune Function Outcomes - a Household Level Randomized mHealth Intervention Trial


Sponsor

International Centre for Diarrhoeal Disease Research, Bangladesh

Enrollment

1,000 participants

Start Date

Jun 20, 2023

Study Type

INTERVENTIONAL

Conditions

Summary

Almost 3 billion people worldwide, including 89% people in Bangladesh, are exposed to harmful household air pollutants (HAP) emitted from combustion of biomass (wood, agricultural residue, cow dung, etc.) fuel use for cooking. While health risks associated with air-pollution have been reasonably well-studied in developed countries, there is little evidence on health benefits achievable by HAP reduction through clean fuel use, especially in low- and middle-income countries (LMICs). Earlier the investigators showed that Liquid Petroleum Gas (LPG) for 24 months, reduced personal PM2.5 exposure by 58.17 percent which induced novel changes in immune and inflammatory responses in the participants; however cardiopulmonary markers remained relatively stable in post-intervention assessment. In this study, the investigators aim to evaluate the effects of mobile phone based (mHealth) Behavioural Change Communication (BCC) intervention on adoption and exclusive use of LPG. The investigators also aimed to observe whether long-term effects of HAP reduction can impact the subclinical measures of cardio-vascular and pulmonary dysfunction and regulate innate and inflammatory immune function among women and children in semi-rural settings in Bangladesh. The investigators will also investigate the influence of exposure to HAP on antibody response to vaccines (adaptive immunity). The BCC intervention will be provided by conducting a large household level randomized controlled trial by educational intervention using mHealth based technology. In addition, the investigators will continue following the cohort and will conduct rigorous and repeated personalized (24 hours) and area (over 5 days) assessments of PM2.5 and black carbon (BC) exposure to examine the long-term effects of HAP reduction on subclinical measures of cardio-pulmonary and immune dysfunction including effect of HAP exposure on antibody response to vaccine.


Eligibility

Sex: FEMALEMin Age: 25 YearsMax Age: 70 Years

Plain Language Summary

Simplified for easier understanding

This study is a follow-up to an earlier environmental health study in Bangladesh. It looks at the long-term effects of indoor air pollution from burning biomass (wood, dung, or crop waste) for cooking on the lung health and immune function of women living in rural Bangladesh. Participants are re-assessed from the original GEOHEALTH study. You may be eligible if: - You are a woman between 25 and 70 years old - You participated in the original GEOHEALTH round-I study - You live in a home that uses biomass fuel and a traditional cooking stove - You are a non-smoker and live with non-smokers - Your drinking water arsenic exposure is below 10 µg/L You may NOT be eligible if: - You have an immune-related illness or take prescription medications (especially those affecting the immune system) - You have had a clinical event related to cardiovascular disease or lung disease (such as a stroke, coronary heart disease diagnosis, or known lung condition) Talk to your doctor to see if this trial is right for you.

This summary was AI-generated to explain the trial in plain language. It is not medical advice. Always discuss eligibility with your doctor before enrolling in a clinical trial.

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Interventions

BEHAVIORALmHealth based behavioral change communication intervention

We will implement a mHealth based communication system. The number of text messages and push notifications that a participant receives, will be variable and will occur at least weekly (based upon their responses) or the participant opts out of receiving messages. Participant change of behavior and use of improved stoves will be monitored by tracking clicks/views of educational materials and video vignettes.


Locations(1)

International Centre for Diarrhoeal Diseases Research, Bangladesh

Dhaka, Bangladesh

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NCT05570552


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