RecruitingNCT05575024

Hemodynamic Stability in Septic Shock Patients Undergoing Continuous Renal Replacement Therapy With oXiris Membrane

Real-time Monitoring of Hemodynamic Stability in Septic Shock Patients Undergoing Continuous Renal Replacement Therapy: Propensity Score-matched Comparison Between oXiris and Polysulfone Membranes


Sponsor

Seoul National University Hospital

Enrollment

98 participants

Start Date

Jan 1, 2024

Study Type

OBSERVATIONAL

Conditions

Summary

The new adsorbing membrane for continuous renal replacement therapy (CRRT), oXiris, can reduce plasma cytokines and endotoxins in septic shock patients with severe acute kidney injury, compared with standard membranes. However, its hemodynamic stability or benefits have not been thoroughly evaluated although this is reasonable.


Eligibility

Min Age: 18 Years

Plain Language Summary

Simplified for easier understanding

This study is looking at whether a special dialysis membrane called oXiris can help stabilize blood pressure and circulation in critically ill patients who have septic shock (a life-threatening infection response) and kidney failure requiring dialysis. The oXiris membrane is designed to remove both toxins and inflammatory molecules from the blood. You may be eligible if: - You are 18 years or older - You have sepsis-related acute kidney injury requiring continuous kidney replacement therapy (dialysis) You may NOT be eligible if: - Your blood pressure and heart rhythm are not being monitored Talk to your doctor to see if this trial is right for you.

This summary was AI-generated to explain the trial in plain language. It is not medical advice. Always discuss eligibility with your doctor before enrolling in a clinical trial.

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Interventions

DEVICEoXiris membrane

Perform continuous renal replacement therapy with oXiris membrane

DEVICEPolysulfone membrane

Perform continuous renal replacement therapy with polysulfone membrane


Locations(1)

Seoul National University Hospital

Seoul, South Korea

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NCT05575024


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