Ketamine in OCD: Efficacy and Effects on Stress and Cognition

This study is testing whether ketamine — a medication used in anesthesia that also shows promise in treating mental health conditions — can reduce obsessive-compulsive disorder (OCD) symptoms. It is also examining how ketamine affects stress and thinking ability. **You may be eligible if...** - You have a primary diagnosis of OCD - Your OCD symptoms are significant (score of 16 or higher on the Yale-Brown OCD scale) - You have tried at least one prior treatment for OCD - You can provide written informed consent **You may NOT be eligible if...** - You have a history of psychotic disorders - You have had a manic episode in the past 3 years - You have unstable substance use or dependence (other than nicotine) - You are pregnant or at elevated risk of becoming pregnant - You have severe personality disorder (other than obsessive-compulsive personality) Talk to your doctor to see if this trial is right for you.