RecruitingNCT05597410

Shanghai At Risk for Alzheimer's Disease: a Cohort Study

Sponsor

Ruijin Hospital

Enrollment

3,418 participants

Start Date

Mar 1, 2022

Study Type

OBSERVATIONAL

Conditions

Cognitive Impairment Dementia Alzheimer Disease Neurocognitive Disorders Neurodegenerative Diseases

Summary

The goal of this cohort study is to estimate the incidence of AD in the first-degree relatives of patients with AD. The main questions it aims to answer are: * cognitive changes of subjects at high risk of AD as ageing; * environmental and behavioral factors affecting AD incidence.

Eligibility

Min Age: 50 Years

Inclusion Criteria5

the AD diagnostic criteria of probands meet the 2011 National Institute on Aging - Alzheimer's Association framework, and participants are the first-degree relatives (including parents, children and siblings of the same father and mother) of the proband;
not patients with dementia;
≥ 50 years, males and females;
subjects have lived in Shanghai for more than 1 year and have no plan to move out of Shanghai within 5 years;
subjects are able to complete investigation, physical examination, imaging examination and biological specimen collection.

Exclusion Criteria5

Individuals will be excluded if they have:
other diseases which could cause cognitive decline, e.g. cerebrovascular diseases, Creutzfeldt-Jakob disease and Parkinsons disease;
history of psychological disorders (according to Diagnostic and Statistical Manual of Mental Disorders, 5th Edition);
uncorrectable visual or auditory impairment that hampers the completion of related examination.
pre-menopausal women will also be excluded.