RecruitingNot ApplicableNCT05597683

Quadratus Lumborum Block After Cytoreductive Surgery and Hyperthermic Intra-peritoneal Chemotherapy

Quadratus Lumborum Block for Analgesia After Cytoreductive Surgery and Hyperthermic Intra-peritoneal Chemotherapy (CRS and HIPEC): a Double-blind Randomized Controlled Trial

Sponsor

Gangnam Severance Hospital

Enrollment

50 participants

Start Date

Nov 15, 2022

Study Type

INTERVENTIONAL

Conditions

Peritoneal Cancer Cytoreductive Surgery Hyperthermic Intra-peritoneal Chemotherapy

Summary

This study aims to assess whether transmusculr quadratus lomborum block (QL block) can reduce postoperative pain after cytoreductive surgery and hyperthermic intra-peritoneal chemotherapy (CRS and HIPEC). Patients will be randomly assigned to either QL block group or control group. Ultrasound-guided bilateral transmuscular quadratus lomborum block will be performed in QL block group using 0.375% ropivacaine. Multimodal analgesic regimen including acetaminophen, nonsteroidal antiinflammatory drugs (NSAIDs), and rescue opioids will be used in every patient. Primary outcome is opioid consumption for 24 hours after surgery. Secondary outcomes included pain scores, time to first rescue analgesics, quality of recovery score, length of hospital stay.

Eligibility

Min Age: 19 Years

Inclusion Criteria1

\- Adult patients who are scheduled to undergo cytoreductive surgery and hyperthermic intra-peritoneal chemotherapy (CRS and HIPEC)

Exclusion Criteria7

Allergy to local anesthetics or fentanyl
Chronic pain
Drug abuse
Patients who are unable to use patient-controlled analgesia
Skin infection at site for quadratus lomborum block
pregnant or breatfeeding women
Patients who are unable to communicate

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Interventions

PROCEDUREArm I (QL block and multimodal analgesia), Arm II (multimodal analgesia without regional block)

Arm I (QL block and multimodal analgesia): Bilateral transmuscular QL block will be done. Postoperative multimodal analgesia including administration of acetaminophen, NSAIDs,nefopam, and rescue opioids Arm II (multimodal analgesia without regional block): No block will be done. Postoperative multimodal analgesia including administration of acetaminophen, NSAIDs, nefopam, and rescue opioids