RecruitingNCT05599178

Doppler Findings in the Fetal Cerebral Blood Vessels (VA/MCA) Within 24 Hours Before Delivery and Relation With Perinatal Outcome.

Sponsor

Universitaire Ziekenhuizen KU Leuven

Enrollment

120 participants

Start Date

Dec 23, 2022

Study Type

OBSERVATIONAL

Conditions

Obstetric Labor Complications Ultrasonography, Doppler

Summary

1. Assess differences in flow patterns in the fetal cerebral blood vessels within 24 hours before delivery between fetuses with a normal vs. adverse perinatal outcome. 2. Explore maternal and/or fetal characteristics that might influence technical feasibility of doppler sonography of the fetal cerebral blood vessels in early labor at term. 3. Assess reliability of the technique by measuring intra- and inter-observer variation in a subset of participants.

Eligibility

Sex: FEMALEMin Age: 18 Years

Inclusion Criteria10

Singleton pregnancy.
Term gestation (37-42 weeks).
Fetus in cephalic presentation.
No known fetal chromosomal or (severe) congenital anomaly.
Normally grown fetus (ultrasound scan demonstrating normal fetal growth between 30-37 weeks of gestation, defined as an estimated fetal weight/abdominal circumference \> 10th centile or crossing \<2 quartiles compared to earlier growth ultrasound).
Absence of pre-existing doppler or amniotic fluid abnormalities.
Normal fetal heart rate tracing / CTG (excluding pre-existing hypoxia).
Admission in early spontaneous labor or induction of labor with expected delivery \< 24 hours.
Maternal age \>= 18 years
Willing to give written informed consent.

Exclusion Criteria4

Advanced labor (\> 4cm of cervical dilatation) at the time of admission on the labor ward.
Severe pre-existing chronic maternal medical condition or poor obstetric history/antenatal complications associated with increased risk of adverse perinatal outcome (non-exhaustive e.g.: uncontrolled chronic hypertension, severe pre-eclampsia, uncontrolled (gestational) diabetes, maternal sepsis, major antepartum haemorrhage, intra-uterine infection, prolonged rupture of membranes \> 18 hours, etc.).
Intra-uterine fetal demise / death.
Prelabour rupture of membranes with meconium-stained amniotic fluid.

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