Correlation Study Between SMA Blood Flow Reactivity and Acute Gastrointestinal Injury in Critically Ill Patients
Correlation Study Between SMA Blood Flow Reactivity and Acute Gastrointestinal Functional Injury in Critically Ill Patients
Peking Union Medical College Hospital
80 participants
Jun 1, 2025
OBSERVATIONAL
Conditions
Summary
This study aims to address the challenges of enteral nutrition support in critically ill ICU patients with varying gastrointestinal function. We'll use bedside Doppler ultrasound to monitor superior mesenteric artery (SMA) blood flow changes post - feeding, exploring its correlation with Acute Gastrointestinal Injury (AGI) and other hemodynamic indicators. Our goals are to identify the patterns of SMA blood flow changes, establish a predictive model linking SMA blood flow reactivity to AGI risk, and propose individualized enteral nutrition strategies based on intestinal hemodynamics. Through this innovative approach, we hope to enhance the safety of enteral nutrition, reduce AGI incidence, and improve patient outcomes.
Eligibility
Inclusion Criteria3
- Adults aged ≥18 years and ≤80 years.
- Admitted to the study with a expected stay of more than 72 hours.
- Require initiation of enteral nutrition support.
Exclusion Criteria5
- Pre-existing severe gastrointestinal diseases.
- Patients with gastrointestinal bleeding.
- Patients with bowel obstruction.
- Pregnant or lactating women.
- Patients with contraindications to bedside Doppler ultrasound.
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Interventions
We'll use an enteral nutrition intervention with intact protein formulations. Initiate nasogastric tube feeding at 20ml/h and continue for 24 hours. Adjust feeding strategies based on patients' SMA blood flow reactivity.
Locations(1)
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NCT07001943