RecruitingNot ApplicableNCT05599568

Repeated Bout Effect i Neuromuscular Diseases


Sponsor

Mads Peter Godtfeldt Stemmerik

Enrollment

50 participants

Start Date

May 15, 2022

Study Type

INTERVENTIONAL

Conditions

Summary

The repeated bout effect (RBE) refers to the adaptation whereby a single bout of eccentric exercise protects against muscle damage from subsequent eccentric bouts. This effect has been shown in many muscle groups using both serum biomarkers, muscle soreness and imaging techniques. Though the effect is well described in healthy, it has never been studied in patients with neuromuscular diseases (NMDs). In healthy, the RBE is only described using eccentric exercise, but unlike healthy persons, patients with NMDs can experience significant muscle damage with concentric exercise. This raises the question, if patients with NMDs could also show RBE when performing concentric exercise.


Eligibility

Min Age: 18 Years

Plain Language Summary

Simplified for easier understanding

This study examines whether people with neuromuscular diseases (conditions affecting muscle function) experience the same protective effect from repeated exercise that healthy people do — known as the 'repeated bout effect.' After a first round of intense exercise, healthy muscles are usually less damaged by a second round. Researchers want to know if this protection also applies to people with these conditions. You may be eligible if: - You are over 18 years old - You have a confirmed molecular diagnosis of a specific neuromuscular condition (or are a healthy control) - You are physically able to complete the exercise challenge - You do not have an active muscle injury on the test day You may NOT be eligible if: - You have heart or lung disease that makes peak exercise testing unsafe (NYHA class III-IV) - Your veins are too difficult to access for blood sampling - You have severe muscle weakness that prevents completing the exercise test Talk to your doctor to see if this trial is right for you.

This summary was AI-generated to explain the trial in plain language. It is not medical advice. Always discuss eligibility with your doctor before enrolling in a clinical trial.

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Interventions

OTHERExercise

Either concentric or excentric exercise


Locations(1)

Neuromuscular Research Unit, 3342

Copenhagen, Denmark

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NCT05599568


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