RecruitingNot ApplicableNCT05613686

Theta Burst Stimulation for Motor Recovery

Comparative Efficacy of Different Doses of Theta Burst Stimulation for Motor Recovery in Stroke Patients

Sponsor

National Taiwan University Hospital

Enrollment

60 participants

Start Date

Oct 29, 2022

Study Type

INTERVENTIONAL

Conditions

Transcranial Magnetic Stimulation

Summary

Repetitive transcranial magnetic stimulation (rTMS) is a non-invasive neuromodulation technology. This study will compare efficacy of different doses iTBS in combination with inhibitory rTMS on motor recovery and cortical excitability in subacute stroke patients.

Eligibility

Min Age: 20 Years

Inclusion Criteria6

Unilateral ischemic or hemorrhagic stroke
Stroke within 3 months
Medical Research Council Scale for Muscle Strength in upper limb ≤ 3
No previous stroke, seizure, dementia, Parkinson's disease or other degenerative neurological diseases.
Patient could sit over 15 minutes
Age over 20

Exclusion Criteria6

Previous stroke, traumatic brain injury, brain tumor
With central nervous system disease (spinal cord injury, Parkinson's disease)
Any contraindication to rTMS (seizure, alcoholism, metal implant, pacemaker)
Patients unable to cooperate the treatment
Pregnancy
Depression

Interested in this trial?

Get notified about updates and connect with the research team.

Interventions

DEVICErepetitive transcranial magnetic stimulation

Repetitive transcranial magnetic stimulation (rTMS) is a non-invasive neuromodulation technology. High and low frequencies of rTMS could modulate the excitability of the cerebral cortex. Theta burst stimulation (TBS) has achieved a similar effect to traditional rTMS mode. Intermittent TBS (iTBS) could upregulate cortical excitability of the primary motor cortex (M1) and continuous TBS (cTBS) with inhibitory effect.