Blood Brain Barrier (BBB) Disruption Using Exablate Focused Ultrasound With Doxorubicin for Treatment of Pediatric DIPG

This study is testing whether using focused ultrasound to temporarily open the blood-brain barrier — the protective wall around the brain — can help the chemotherapy drug doxorubicin reach brain tumors more effectively in children with a type of inoperable brainstem cancer called DIPG. **You may be eligible if...** - You are between 5 and 18 years old - You have been diagnosed with DIPG (diffuse intrinsic pontine glioma), a type of brainstem tumor - You finished radiation therapy 4–12 weeks ago - Your recent brain scan does not show signs of tissue death or bleeding - Your life expectancy is at least 6 months - You (or a parent/guardian) are able and willing to give consent **You may NOT be eligible if...** - You have a brain or body infection - You have already received the maximum safe dose of certain chemotherapy drugs (anthracyclines) - You have HIV or another immune-suppressing condition - You have active seizures that are not controlled by medication - You are allergic to the ultrasound contrast agent or to gadolinium (MRI dye) Talk to your doctor to see if this trial is right for you.