The Evolution and Prognosis of Moyamoya Disease

This study follows patients with Moyamoya Disease — a rare brain blood vessel condition where the major arteries at the base of the brain become progressively narrowed or blocked, leading to strokes or other brain problems. Tiny new blood vessels form to compensate, creating a hazy appearance on scans (resembling a puff of smoke — hence "moyamoya" in Japanese). The study tracks how the disease evolves and affects thinking, memory, and quality of life over time. You may be eligible if: - You are between 10 and 60 years old - You have been diagnosed with Moyamoya Disease confirmed by angiography or MRI - You completed at least a primary school education (6 or more years of schooling) - You have signed informed consent You may NOT be eligible if: - You have had a massive brain infarction, multiple deep brain bleeds, or severely enlarged ventricles - You have vascular disease caused by an immune system disorder - You are unable to complete cognitive function tests - You have other neuropsychiatric conditions affecting cognition (e.g., Alzheimer's, Parkinson's, depression, anxiety disorder) - You have metal implants, a pacemaker, or other MRI contraindications Talk to your doctor to see if this trial is right for you.