MRI-Guided Focused Ultrasound Radiosensitization for Patients With Malignant Melanoma and Non Melanoma Skin Cancer

This study is testing whether using MRI-guided focused ultrasound — a non-invasive technology that uses sound waves to heat tissue — before radiation therapy can make skin cancer (melanoma and non-melanoma) more sensitive to radiation, potentially improving treatment outcomes. **You may be eligible if...** - You are 18 or older with biopsy-confirmed malignant melanoma or non-melanoma skin cancer (including metastatic lesions) - You are referred for radiation therapy and are also on immunotherapy - Your target tumor is visible on MRI and accessible for the focused ultrasound procedure - You weigh less than 140 kg and can hold still during treatment - Your kidney function meets required levels **You may NOT be eligible if...** - You are pregnant or breastfeeding - You are unable to have a contrast-enhanced MRI scan - Your tumor has broken through the skin surface causing ulceration or bleeding - You have severe heart, brain, kidney, or blood problems - Your general health is too poor (ECOG 3 or worse) or you cannot hold still during treatment Talk to your doctor to see if this trial is right for you.