RecruitingPhase 3NCT05620784

Intra-operative Loop Diuretics to Improve Same-day Discharge Rates After HoLEP

Loop Diuretics During Morcellation to Improve Same-day Discharge Rates After Holmium Laser Enucleation of the Prostate (HoLEP)


Sponsor

Northwestern University

Enrollment

138 participants

Start Date

Mar 1, 2023

Study Type

INTERVENTIONAL

Conditions

Summary

Holmium Laser Enucleation of the Prostate (HoLEP) is a size-independent treatment option for benign prostatic hypertrophy (BPH) as recommended by the American Urological Association (AUA) Guidelines. Loop diuretics (furosemide) have been given historically during the morcellation portion of HoLEP to promote urine production in the post-operative setting and to minimize the impact of fluid absorption during long periods of morcellation. The intra-operative use of 20mg IV furosemide in perioperative HoLEP pathways has been propagated with the dissemination of HoLEP across North America without evidence to support its routine administration. With increasing surgical efficiency from improvements in laser and morcellator technology, the role of intra-operative furosemide is unknown. This study is designed to assess if there is a significant difference in same day discharge rates after Holmium Laser Enucleation of the Prostate (HoLEP) with and without IV furosemide. .


Eligibility

Sex: MALEMin Age: 18 YearsMax Age: 89 Years

Plain Language Summary

Simplified for easier understanding

This study tests whether giving a loop diuretic (furosemide) during surgery can help patients go home the same day after having a HoLEP procedure — a laser surgery to treat enlarged prostate (benign prostatic hyperplasia, or BPH). After HoLEP, patients often cannot urinate right away and need to stay in the hospital overnight. Furosemide may help speed up the return of normal urination. You may be eligible if: - You are a male between 18 and 89 years old - You are scheduled for a HoLEP procedure - You are able to read, understand, and complete questionnaires - You signed the informed consent form You may NOT be eligible if: - You have an allergy or hypersensitivity to furosemide or other loop diuretics - You produce no urine (anuric) or have liver failure - You are having additional urologic or non-urologic surgery at the same time as HoLEP - You are expected to need a perineal urethrostomy during the procedure - You will not be having your catheter removed and voiding trial done at Northwestern Memorial Hospital Talk to your doctor to see if this trial is right for you.

This summary was AI-generated to explain the trial in plain language. It is not medical advice. Always discuss eligibility with your doctor before enrolling in a clinical trial.

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Interventions

DRUGFurosemide

20mg of IV furosemide injection during the morcellation phase of HoLEP


Locations(1)

Northwestern University

Chicago, Illinois, United States

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NCT05620784


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