Quantifying Systemic Immunosuppression to Personalize Cancer Therapy

This study is measuring how much the immune system is suppressed in people with various advanced cancers, to develop a test that can predict which patients are most likely to benefit from immunotherapy and help personalize their cancer treatment. **You may be eligible if...** - You are between 18 and 90 years old with a confirmed diagnosis of metastatic or locally advanced melanoma, breast cancer, kidney cancer, bladder cancer, head and neck cancer, squamous cell carcinoma, or non-small cell lung cancer (including resectable stage III lung cancer) - Your general health score is 0–2 - You have a tumor tissue sample available for testing - You are willing to complete a socio-economic and psychological survey **You may NOT be eligible if...** - You have a known HIV infection - You have a serious neurological or psychiatric disorder - You are pregnant or breastfeeding - You are unable or unwilling to provide informed consent or attend regular follow-up at the same center Talk to your doctor to see if this trial is right for you.