RecruitingNot ApplicableNCT05626491

Electrical Stimulation for the Treatment of Glaucoma

Evaluate the Safety and Efficacy of Repetitive, Transorbital Alternating Current Stimulation (rtACS) for the Treatment of Glaucoma


Sponsor

Stanford University

Enrollment

45 participants

Start Date

Feb 28, 2023

Study Type

INTERVENTIONAL

Conditions

Summary

The overall aim of this study is to see whether long-term electrical stimulation with a home-stimulation device works well and is safe for the treatment of open-angle glaucoma. Open-Angle Glaucoma is a disease where the nerves in the back of your eye die off faster than expected regardless of your eye pressure.


Eligibility

Min Age: 18 Years

Plain Language Summary

Simplified for easier understanding

This study is testing whether a non-invasive electrical stimulation device applied near the eye can improve vision in people with moderate to severe glaucoma. By delivering gentle electrical pulses, the device aims to stimulate the optic nerve and potentially preserve or partially restore remaining vision. **You may be eligible if...** - You are 18 or older with a confirmed glaucoma diagnosis - You have moderate to severe vision field loss (mean deviation worse than -3 and visual field index between 10–90%) - Your corrected visual acuity is no better than 20/200 (legally blind range) - Your eye pressure is considered clinically stable by your doctor **You may NOT be eligible if...** - You have a pacemaker or other implanted electronic device - You have significant retinal disease, corneal problems, uveitis, or eye herpes - You are currently participating in another eye drug trial - You are pregnant or breastfeeding - You have dementia or another condition that would interfere with participation Talk to your doctor to see if this trial is right for you.

This summary was AI-generated to explain the trial in plain language. It is not medical advice. Always discuss eligibility with your doctor before enrolling in a clinical trial.

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Interventions

DEVICERepetitive, Transorbital Alternating Current Stimulation (rtACS)

Patients receive treatment every other day via a headband that delivers electrical stimulation to the retina

DEVICESham Repetitive, Transorbital Alternating Current Stimulation (rtACS)

Patients receive sham treatment (no active stimulation) every other day via a headband.


Locations(4)

Byers Eye Institute

Palo Alto, California, United States

NYU- Langone

New York, New York, United States

Wills Eye Hospital

Philadelphia, Pennsylvania, United States

Otto-von-Guericke University

Magdeburg, Germany

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NCT05626491


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