INflammation-based Stratification for Immune-Targeted Augmentation in Major Depressive Disorder

This study is investigating whether an anti-inflammatory add-on treatment can help people with major depression whose blood shows elevated markers of inflammation and who have not fully responded to their current antidepressant, based on the idea that inflammation in the brain may drive treatment-resistant depression in some people. **You may be eligible if...** - You are between 18 and 65 years old - You have a confirmed diagnosis of major depressive disorder (MDD) - Your depression has not fully improved on your current antidepressant, taken at an adequate dose for at least 4 weeks - You are physically healthy - Women of childbearing age must use contraception **You may NOT be eligible if...** - You have bipolar disorder or a psychotic condition - You have a serious physical health condition that could interfere with the study - You plan to change your antidepressant during the study - You have an active inflammatory disease or infection Talk to your doctor to see if this trial is right for you.